PPT-3. Synaptic transmission

Review What decision is made by a neuron At what location the decision is made How the decision is made Simple decision rule if E m gt threshold 40mV fire an action potential. This inter pretation is still a matter of debate its resolution is important for our understanding of the nature of quantal response In this work we explore observable consequences of the univesicular release hypothesis by studying a stochastic mode Balanced and unbalanced transmission line Transit time effect on a transmission line at high frequencies Dominance of the reactive component over resistive component Concept of distributed elements and conditions under which the lumped element circu •Introduction into synaptic transmission ConventionalSynapse RibbonSynapse Action potentialsdrivephasicall ornone Transmission isgovernedbygradedpotentialsand Principles of synaptic transmissio Understanding:. Neurons transmit electrical impulses. The myelination of nerve fibers allows for salutatory conduction. Neurons pump sodium and potassium ions across their membranes to generate a resting potential . t. hrough RNA editing . Previous studies have identified neuronal overgrowth to be in response to malfunctions of two genes, FMR1 and ADAR, which encode RNA binding proteins in . Drosophila. . that . Quantal analysis. Indexing synaptic transmission (a number). The . neuromuscular junction. Whiteboard work- NMJ history of quantal synaptic transmission. Katz 1954.. Mean quantal content =. ∑ (# of failures)(0) + (# of singles)(1)+ (# of doubles)(2)…. Caitlin Hof & Steven Larson. Spike Timing Measurements. Measures the firing rate of neurons. Is assumed to be a correlate to working memory. Is done with single neuron electrodes (electrophysiology) and EEG. Communication between neurons. Communication between neurons. S. taggering . diversity of synapse morphologies and types in the . brain. Fundamental . process of synaptic transmission . same. A key quantity in neural circuits is the synaptic efficacy or strength, which varies over time. . Parkinsons-2015August 11-13, 2015August 11-13, 2015 Frankfurt, Germany International Conference on Page 30 Nigro-striatal DA neurons in the world of volume transmission and heteroreceptor complexes: . Professor. , Department . of Pharmacology and Neuroscience. . . Chapters 4 and 6 . in Neuroscience . 5. th. Edition text . (Purves et al.). Neurotransmission:. Introduction to neurotransmitters, channels, and transporters. . As many as 10,000 to 200,000 . minute synaptic knobs called presynaptic terminals . lie on the surfaces of the . dendrites and soma . of the motor neuron, with about 80 to 95 percent of them on the dendrites and only 5 to 20 percent on the soma. Otto Loewi 1926. Synapse Types. Anatomical. Axodendritic. , . axosomatic. , . axoaxonic. Physiological . Electrical, chemical. Functional. Excitatory, inhibitory, . modulatory. Electrical . vs. Chemical Synapse. Specific learning outcomes. Define synapse. Describe the types of synapses. Describe the structure and features of types of chemical synapses. Outline the process of chemical synaptic transmission. Explain the types of inhibition at synapses. How do our neurons communicate with each other?. Chemical Signal. Electrical Signal. Do Now:. Sleeping Beauty just pricked her finger and is feeling a lot of pain. Model the neurons involved in Sleeping Beauty sensing this pain. .