PPT-Oxidative Inhibition of Erythrocyte Na

K Pump A Functionally Relevant Circulating Marker of Oxidative Stress Dr Chiachi Liu Molecular Cardiac Research Unit Sydney Medical School University of Sydney Australia Outline. 1 Competitive Inhibition Fig 8- 2 Competitive InhibitionCTEuli S + S E P + E c = K . ( [ c / K c / Vx sl re S bu i n a S bd t fee E a a s wre S bd c w S f fee E S Inhibition is a term used to describe the inability of a product being formed due to the presence of another substance (the inhibitor). Enzyme inhibition . can be competitive or noncompetitive. Competitive inhibition is caused when an inhibitor “competes” with the substrate in binding with the enzyme. Pratt & . Cornely. . Ch. 7. Other Factors. Other factors affect enzyme activity. Temperature. pH . pH Optimum. Determined by structural stability. Compartmentalization. Determined by active site residues. & . Elimination. Dr. Sandro Percario. Editorial . Board Member. Professor. Ph.D., Federal University of . Para, Brazil. Guest Researcher. US Centers for Disease Control and Prevention, . USA. .. Oxidative Stress. O. 2. is readily reduced to form one of many Reactive Oxygen Species (ROS) . ROS cause cellular damage. DNA. Protein. Lipids. http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/ros.gif. By: . Jingtian. . Weng. , Cindy Nguyen, Cassandra Lee, Sarah Bento-De Sousa. Presentation Date: Sept. 13, 2016. PHM142 Fall . 2016. Instructor: Dr. Jeffrey Henderson. What is COX?. Two homodimer enzymes COX-1 and COX-2. Chapter 26, . Stryer. Short Course. Glucose Metabolism Overview. Gluconeogenesis. Glycogen . metabolism. Pentose Phosphate Pathway. Pentose Phosphate Pathway. Dual Purpose. Synthesis of “reducing potential”. Pratt and . Cornely. , Chapter 15. Goal: ATP Synthesis . Overview. Redox reactions. Electron transport chain. Proton gradient. ATP synthesis. Shuttles. Standard Reduction Potential. “potential to be reduced”. Pratt & . Cornely. . Ch. 7. Enzyme Kinetics. How fast an enzyme catalyzed reaction goes. Why study enzyme kinetics?. Helps us understand mechanism of enzyme (how it works). Investigation of mutations in metabolic pathways. Clinical Chemistry Unit Pathology Department. College of Medicine, KSU. Objectives. By the end of the lecture, students are expected to:. Define a metabolic pathway.. Describe the general metabolic pathways for glucose (production and utilization). Kenneth Cintron, MD, FAAOS, ABoIM, MBA. Southeast Orthopedic Specialists. Jacksonville, . Florida, USA. 3. rd Annual Medical Conference . & . Community Outreach Program. . June . 10, 11 & 12, 2016. . Igor Theurl1–3,17, Ingo Hilgendorf1,2,4,17, Manfred Nairz1,2,17, Piotr Tymoszuk3, David Haschka3, Malte Asshoff3, Shun He1,2, Louisa M S Gerhardt1,2, Tobias A W Holderried5, Markus Seifert3, Sieghart Sopper6, Ashley M Fenn1,2, Atsushi Anzai1,2, Sara Rattik1,2, Cameron McAlpine1,2, Milan Theurl7, Peter Wieghofer8,9, Yoshiko Iwamoto1,2, Georg F Weber1,2, Nina K Harder1,2, Benjamin G Chousterman1,2, Tara L Arvedson10, Mary McKee1,11, . At the end of this unit of study, the student should be able to:. List and describe the stages of erythrocyte maturation in the marrow from youngest to most mature cells.. Explain the maturation process of reticulocytes and the cellular changes that take place.. doi: 10.5505/kjms.2019.67934 Ergn Takn, Kaas Ünverstes, Tp Fakültes Dekanlk Bnas, B114, Kars, Türkye Tel: of 658 patients were inc