PDF-In this and the next lecture, we will be concerned with diuretic drugs

Therefore a major clinical use of diuretics is to reduce edema There are three most common usesof diuretics First is to reduce edema the abnormal accumulation of interstitial fluid resulting inth. Drugs. Diuretics. A chemical agent that increases the rate of urine formation.. Reabsorption of Na in the kidney results in the reabsorption of water. It follows that inhibition of Na reabsorption will result in diuresis. Because of this, the term diuretic has come . Treatment of Hypertension . Update 2012. Cost Effectiveness of Antihypertensive Treatment 2011. “Treating high blood pressure is cheaper than doing nothing. ”. Step 1 Treatment Recommendations. Offer step 1 antihypertensive treatment with an ACE inhibitor or an ARB to people aged under 55 years. If an ACE inhibitor is used and not tolerated, offer an ARB. [new 2011] . Learning Objectives. Classify. . the diuretic agents. Describe. . the mechanism of diuretic agents. Demonstrate. the pharmacological effects of typical diuretic agents. Propose. the rational clinical application . Pathophysiology & Cases Discussion. Bambang. Budi . Siswanto. Prof MD, PhD, FIHA, . FAsCC. , FAPSC, FESC, FACC, FSCAI. Dept. Cardiology and Vascular Medicine University Indonesia. Medical Research Unit & Medical Education Unit & Coordinator Collaboration FKUI. Dr. Pran Kishore Deb & Dr. . Bilal Al-. jaidi. Assistant Professor, Pharmaceutical Medicinal Chemistry. Faculty of Pharmacy, Philadelphia University-Jordan. Email: . pdeb@Philadelphia.edu.jo. . Diuretics. (Phil. . 2:19-30. CONCERNED. Focused on others. Motivates others. Promotes action. Welcomed by others. Driven by love. Goal is to help. Strengthens relationships. Tempered with faith. . . WORRIED. Self serving. Update 2012. Cost Effectiveness of Antihypertensive Treatment 2011. “Treating high blood pressure is cheaper than doing nothing. ”. Step 1 Treatment Recommendations. Offer step 1 antihypertensive treatment with an ACE inhibitor or an ARB to people aged under 55 years. If an ACE inhibitor is used and not tolerated, offer an ARB. [new 2011] . . Most diuretic agents are inhibitors of renal ion transporters that decrease the . reabsorption. of Na+ at different sites in the . nephron. . . As a result, Na+ and other ions, such as . Cl. −, enter the urine in greater than normal amounts along with water, which is carried passively to maintain osmotic equilibrium.. Carbonic anhydrase is in the PCT, where it catalyzes the dehydration of H. 2. CO. 3. .. By blocking carbonic anhydrase, drugs block NaHCO3 reabsorption and cause diuresis.. Carbonic anhydrase inhibitors are now rarely used as diuretics. Diuretics . Mohammed Al-Manna . Doctor of pharmacology and therapeutics. Filtration rate = GFR. Edema . Edema. is movement of fluid from vascular compartment into . interstitial space.. Edema is normal response of the body to injury or inflammation .. Vol. No XV 3 January 1996, Pages 190 - 212 MEDICINAL PLANTS OF RAJASTHAN IN INDIAN SYSTEM OF MEDICINE Y.C. TRIPATHI, V.V PRABHU, R.S PAL and R.N MISHRA Arid forest Research institute, Jodhpur – 342 Characteristics, classification, relationship between structure and pharmacological action, mechanism of action, methods of production, methods of analysis, . application . in medicine ". MEANS AFFECTING THE SELECTIVE SYSTEM. Assistant. . lec. . . Shaymaa. Hasan Abbas. Diuretics. . Thiazides and related diuretics. - . Thiazides. and related compounds . are moderately potent diuretics; they inhibit sodium . reabsorption. Eric Klug. Fluid Overload. Congestion is a primary cause of worsening heart failure and HF hospitalisation. Residual congestion at the time of discharge is a strong predictor of poor clinical outcomes and hospital readmission.