PPT-Peginterferon

Author : tawny-fly | Published Date : 2017-12-16

alfa 2b RBV vs Peginterferon alfa 2a RBV IDEAL STUDY Phase 3 Treatment Naïve Treatment Naïve Chronic HCV McHutchison JG et al N Engl J Med 200936158093

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Peginterferon: Transcript

alfa 2b RBV vs Peginterferon alfa 2a RBV IDEAL STUDY Phase 3 Treatment Naïve Treatment Naïve Chronic HCV McHutchison JG et al N Engl J Med 200936158093 . RESPOND-2. Phase . 3. Treatment. . Experienced. Bacon BR, et al. N . Engl. J Med. 2011;364:1207-17.. Source: . Bacon BR, et al. N Engl J Med. 2011;364:1207-17.. Boceprevir for Retreatment of HCV Genotype 1 Infection . Genotype . 1 . (. Viral . Relapsers. ). PROMISE . Trial. Phase . 3. Treatment. . Experienced. Forns. X. , . et al. . Gastroenterology. 2014;146:1669-79.e3.. Source: . Forns. X. , et al. Gastroenterology. 2014;146:1669-79.e3.. Treatment –Experienced Genotype . 1 . ASPIRE Trial. Phase . 3. Treatment. . Experienced. Z. euzem. S. , . et al. . Gastroenterol. . 2014;146:430-41.. Source: . Zeuzem. S. , et al. . Gastroenterol. versus . Telaprevir. . with PR in GT1 . ATTAIN Trial. Phase . 3. Treatment. . Experienced. Reddy KR. , . et al. . Lancet Infect Dis. 2015;15:27-35.. Source: Reddy KR. , et al. Lancet Infect Dis. 2015;15:27-35.. alfa-2a . versus. . Interferon . alfa-2a. Phase 3. Treatment. . Naïve, Chronic HCV. Zeuzem. S, et al. N . Engl. J Med. 2000;343:1666-72.. Source: . Zeuzem. S, . et al. . N Engl J Med. 2000;343:1666-72.. versus. . Interferon alfa-2b + Ribavirin . Phase 3. Treatment. . Naïve, Chronic HCV. Manns. . MP, et. al. Lancet. 2001;358:958-65. Peginterferon alfa-2b + Ribavirin . versus . Interferon alfa-2b + Ribavirin . Pegasys. ). Prepared by: David Spach, MD & H. Nina Kim, MD. Last Updated: February . 14, . 2014. Background and Dosing. Peginterferon alfa-2a (. Pegasys. ). Peginterferon alfa-2a (. Pegasys. ). Summary. with PEG + RBV in Genotype 1. SPRINT. -1. Phase . 2. Treatment. . Naïve. Kwo. PY, et al. Lancet. 2010;376:705-16.. Source: . Kwo PY, et al. Lancet. 2010;376:705-16. .. Boceprevir . for Treatment-Naïve HCV Genotype 1. . or 3 . LONESTAR-2. Phase 2. Treatment. . Experienced. Lawitz. . E, et al. . Hepatology. . 2015:61:769-75.. Source: . Lawitz. E, et al. . Hepatology. . . 2015:61:769-75.. Sofosbuvir + . PEG + RBV . RBV . versus. Interferon alfa. -. 2a + RBV . ACTG 5071. Phase . 2. Treatment. . Naïve, Chronic HCV and HIV. Chung RT, . et. al. N . Engl. J Med. . 2004;351:451-9. . PEG alfa. -2a . + . RBV . versus. . Interferon . alfa-2a. Phase 3. Treatment. . Naïve, Chronic HCV. Zeuzem. S, et al. N . Engl. J Med. 2000;343:1666-72.. Source: . Zeuzem. S, . et al. . N Engl J Med. 2000;343:1666-72.. Peginterferon alfa-2a versus Interferon alfa-. versus. Interferon alfa-2b + Ribavirin. Phase 3. Treatment. . Naïve, Chronic HCV. Fried MW, . et al. N . Engl. J Med. . 2002;347:975-. 8. 2. .. Peginterferon +/- Ribavirin versus Interferon + . Ribavirin. Chronic hepatitis C virus (HCV) infection is one of the most common chronic liver disease and accounts for 8000 to 13,000 deaths each year. . The majority of liver transplants performed in the United States are for chronic HCV. . ID . : . DB00008 . Protein average . weight : . 60000.0000. . Half life : . Terminal half life is 80 hours (range 50 to 140 hours). . . Description. :. . Human interferon 2a, is a covalent conjugate of recombinant alfa-2a interferon with a single branched .

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