PPT-Carbocation Rearrangements

93 Hydride shifts give new S N 1 products Treatment of substituted secondary alcohols produces unexpected results Rearrangement of an initial secondary carbocation to the more stable tertiary carbocation by a hydride shift results in a rearranged product. Carbocation is already tertiary !!There is no ring strain !!Then why should it rearrange? B'Molecular Rearrangements Pinacol-Pinacolone Rearrangement Pinacol Mechanism : Alkyl group which is anti to t 5453 and Glenn California Institute of Technology, Pasadena, California, 125 and Los Angeles. California, Abstract: A stereoselective total synthesis of As a [2,3]-sigmatropic rearrange- constitut Si Group . seminar. – . LSPN . – 30/04/15 . Selected examples of . spirocyclic. natural product synthesis. Structures . with. multiple rings . connected. . through. one . atom. Nomenclature . proposed. Substitution Reactions. (Substitution at sp. 3. -hybridized Carbon). Halides are electronegative elements. Thus, in the case of an alkyl halide, R-X the halide atom can leave from carbon, taking the shared pair of electrons with it.. .* * *Two ways in which substituents donate or withdraw electrons:What makes the substituent UNIQUE compared to the other hydrogen atoms attached to thebenzene ring? (resonance, higher electronegativi from Biological . Problem to . Combinatorial Algorithms. (and back). Pavel Pevzner. Department of Computer . Science,. . University . of California at San Diego. What is the evolutionary scenario for transforming one genome into the other?. Carbocations. Substitution and . β. -elimination reactions at C(sp. 3. )-X. Electrophilic addition to . nuclephilic. C=C . π. bonds. Substitution . at . nuclephilic. C=C . π. . bonds. Nuclephilic. 12-1. Because the C-C .  bond is relatively weak, alkene chemistry is dominated by its reactions.. The addition of a reagent, A-B, to give a saturated compound is the most common transformation of an alkene.. e. nergies & . t. ransition states. 7.2 Review of acid-base reaction mechanisms. 7.3 Writing reactions as transformations. 7.4 Substitution reactions. 7.5 Addition reactions. 7.6 Elimination reactions. chromosome with a segment (heavy line) flanked by natural inverse-order repeats. In principle, inversionscan form by either intra- or interchromosomal exchanges. The left side of the figure diagrams i xFICTION Fluorescence immunophenotyping and interphase cytogenetics as a tool for investigation of neoplasmsCT Chromosome territoryMultiple myeloma MM is a clonal plasma cell proliferative disorder , Seda Klç , Demet Akdeniz , Özge ükrüolu , eref Bura Tuncer , Mukaddes Avar Gözde Kuru , Betül Çelik , Seden Küçücük , Pnar Saip Department of Cance signicance dicult to ascertain []. ere are numerous other common cytogenetic ndings that are not routinely used for risk stratication, including 11q23 rearrangements, despite their prevalence in