PPT-Strategy for incorporating newly discovered causative genetic variants into genomic evaluations

Abstr 16462 Causative variants Benefits of knowing causative variant Supports an exact test particularly useful for undesirable conditions No linkage decay when used in evaluation Increased reliability of genomic evaluations as causative variants replace less informative SNP. breed composition for crossbred U.S. dairy cattle . Introduction. Traditional evaluations are on all-breed base. Pedigree breed composition (PBC) has been computed, distributed, and used to calculate heterosis since we went to the all-breed model in . Bioinformatics and Genomics. Applications:. Personalized cancer medicines. Disease determination . Pathway Analysis. Biomarker Discovery . An Interesting Point. “One . article estimated that the output from genomics may soon dwarf data heavyweights such as . Ben Ho Park MD PhD. Johns Hopkins University. Financial Disclosures. I have financial relationships with commercial entities that are relevant to the content of this presentation.. Royalties from Horizon Discovery, LTD. Jack K. . Okamuro. National Program Leader for Plant Biology, . Crop . Productoin. & Protection, USDA-ARS. ARS Administrator’s Council Meeting. December 5, 2012. Beltsville, MD. Challenge. Food Security & Sustainability. Comm. 301. Reasons for changes in SNP set. History. Single list created across breeds. Poor performing SNPs removed. SNP selection criteria changed. Updated assembly changed SNP locations. Additional QTLs as . Species. Just when you thought you’d seen it all, a load of bizarre new animals get discovered... Lasiognathus. . Dinema. Discovered in 2016, this species of anglerfish is probably the ugliest on the list. Nevertheless, it isn’t the least interesting as the . Length. as . a Trait of the Service Sire . J.R. . . Wright. , . P.M. . VanRaden. ,* . and . J.L. . Hutchison. Animal Genomics . &. . Improvement Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705-2350. A “big data” project of the . Animal Genomics and Improvement Laboratory (AGIL). AGIL mission. Discover and develop improved methods for the genetic and genomic evaluation of economically important traits of dairy animals and small ruminants. A “big data” project of the . Animal Genomics and Improvement Laboratory (AGIL). AGIL mission. Discover and develop improved methods for the genetic and genomic evaluation of economically important traits of dairy animals and small ruminants. George Wiggans, CDCB Technical Advisor. Highlights of U.S. system. Over half a million animals genotyped in 2016. 67% of AI breedings to genomic bulls. Genomic relationship between genotyped cows and marketed bulls available. ? . An . introduction to human . genomics. Jacques Fellay. EPFL School of Life Sciences. Swiss Institute of Bioinformatics. Lausanne, Switzerland. What is . the genome?. “It's . a . shop manual. , with an incredibly detailed blueprint for building every human cell.. Dairy Cattle. 9 million cows in US. Attempt to have a calf born every year. Replaced after 2 or 3 years of milking. Bred via AI. Bull semen collected several times/week. Diluted and frozen. Popular bulls have 10,000+ progeny. intergenic long noncoding . RNAs. Project for “Solving Biological Problems that require Math”. Jennifer Tan. Intergenic. long noncoding RNAs. Pervasive transcription of eukaryotic genomes (not just in protein-coding regions). biology – lessons from dairy cattle breeding. Dairy Cattle. 9 million cows in US. Attempt to have a calf born every year. Replaced after 2 or 3 years of milking. Bred via AI. Bull semen collected several times/week. Diluted and frozen.