PPT-Strategy for incorporating newly discovered causative genetic variants into genomic evaluations

Abstr 16462 Causative variants Benefits of knowing causative variant Supports an exact test particularly useful for undesirable conditions No linkage decay when used in evaluation Increased reliability of genomic evaluations as causative variants replace less informative SNP. breed composition for crossbred U.S. dairy cattle . Introduction. Traditional evaluations are on all-breed base. Pedigree breed composition (PBC) has been computed, distributed, and used to calculate heterosis since we went to the all-breed model in . Bioinformatics and Genomics. Applications:. Personalized cancer medicines. Disease determination . Pathway Analysis. Biomarker Discovery . An Interesting Point. “One . article estimated that the output from genomics may soon dwarf data heavyweights such as . By Mr. Gaviria. The passive causative. Use the passive causative to talk about services you arrange for someone to do for you.. have. I. object. Past participle. had. t. he house. repainted. The passive causative. Causative. We use a Causative verb when we want to talk about something that someone else did for us or for another person. It means that the subject caused the action to happen, but didn’t do it themselves. Maybe they paid or asked or persuaded the other person to do it. For . Ben Ho Park MD PhD. Johns Hopkins University. Financial Disclosures. I have financial relationships with commercial entities that are relevant to the content of this presentation.. Royalties from Horizon Discovery, LTD. Genomic Medicine. In announcing on June 26, 2000, that the first draft of the human genome had been achieved, President Clinton said it would “revolutionize the diagnosis, prevention and treatment of most, if not all, human diseases.”. Jack K. . Okamuro. National Program Leader for Plant Biology, . Crop . Productoin. & Protection, USDA-ARS. ARS Administrator’s Council Meeting. December 5, 2012. Beltsville, MD. Challenge. Food Security & Sustainability. Species. Just when you thought you’d seen it all, a load of bizarre new animals get discovered... Lasiognathus. . Dinema. Discovered in 2016, this species of anglerfish is probably the ugliest on the list. Nevertheless, it isn’t the least interesting as the . Abstract #461. Background - Crossbreeding. Harris and Johnson (2010) . used multibreed relationship matrix to obtain GEBVs in NZL. Olson et al (2010) . estimated MT multi-breed SNP effects and genomic breed composition. A “big data” project of the . Animal Genomics and Improvement Laboratory (AGIL). AGIL mission. Discover and develop improved methods for the genetic and genomic evaluation of economically important traits of dairy animals and small ruminants. ForewordOne secret weapon has helped beat every disease outbreak over the last century but it is not masks or social distancing lockdowns or even vaccines Instead it is data Data tells us which masks Dairy Cattle. 9 million cows in US. Attempt to have a calf born every year. Replaced after 2 or 3 years of milking. Bred via AI. Bull semen collected several times/week. Diluted and frozen. Popular bulls have 10,000+ progeny. American Journal of Obstetrics & Gynecology 2015. Alastair MacLennan. , Emeritus Professor Obstetrics & Gynaecology,. Suzanna Thompson. , . Paediatric. Neurology,. Jozef Gecz. , Professor of Neurogenetics Research. Dr. Breno Fragomeni. Assistant Professor. Animal Science - UConn. Where are the labels?. Introduction . Why genomic prediction?. Higher accuracy. Shorter generation interval . Higher genetic gain. Genetic gain per year.