Institute for Clinical and Translational Research And Translational Laboratory Cores Craig Hendrix MD ICTRCFAR Lab Core Director chendrixjhmiedu 4109559707 Curt Reynolds MAS ID: 1043792
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1. New Approaches to Metabolomics ResearchInstitute for Clinical and Translational ResearchAndTranslational Laboratory CoresCraig Hendrix, MD, ICTR/CFAR Lab Core Directorchendrix@jhmi.edu, 410-955-9707Curt Reynolds, MAS, ICTR/CFAR Lab Core Project Managercjreyn@jhmi.edu, 443-287-3060
2. What can ICTR do for you?http://ictr.johnshopkins.edu/Organized into 6 CoresTranslational Laboratory Core (TLC)Human Subjects Research CoreQuantitative Methodologies CoreInformatics CoreResearch Participant and Community Partnership CoreEducation, Training and Career Development Core…and 2 stand-alone programsThe Studio/Navigation ProgramTranslational Research Communities
3. Pilot Fundinghttp://ictr.johnshopkins.edu/Objective: Targeted Funding & Engaged Management to Advance Translational ResearchAccelerated Translational Incubator Program (ATIP)Funding requests one to two times per year.Approximately 5-10 awards made per year.Awards up to $100,000 in direct costs (no salary support)12-month accelerated funding periodNexus AwardsGap targeted RFA from each Research communityBiomarker and Diagnostic Testing Drugs/Biologics/Vaccines/DevicesBehavioral, Social, and Systems ScienceFunding/timing similar to ATIP
4. Pilot Fundinghttp://ictr.johnshopkins.edu/Doris Duke Early Clinical Investigator Award1 – 2 years of funding of $30,000 – 40,000 per year to fund salary or other research support needsComprehensive support program that integrates supplemental financial resources with guidance for career development services, and ongoing mentoring. Support may include:Salary support for research coordinator, biostatistician, data base specialist, help with access to clinical data, writer;Salary support to allow more research time (e.g., reduce clinical obligations)SOM Discovery Fund For Synergy and Innovation AwardProvide grant awards to cross-divisional teams, comprised of faculty and/or non-faculty members from at least two schools or affiliates of the university, who are poised to arrive at important discoveries or creative works.The expectation is that these awards will spark new, synergistic interactions between investigators across the institution and lead to work of the highest quality and impact.
5. Translational Laboratory Core (TLC) Provide state-of-the-art conceptual and technical laboratory supportDeliver services to translational scientistsPriority to ATIP developmental grants, junior, and new translational scientists11 service core laboratories provide:ConsultationAssay developmentSample analysisCoordination with ICTR Clinical Services, Studios, Communities Costs subsidized; depend on investigator funding
6. TLC LaboratoriesDrug Development Resources & ServicesDrug Analysis UnitsAssay development, sample analysis, pharmacokinetics, pre-clinic study designOncology Michelle Rudek , (mrudek2@jhmi.edu, 443-287-6476)Clinical Pharmacology Analytical Lab (CPAL) Mark Marzinke (mmarzin1@jhmi.edu, 410-502-7691)Medicinal Chemistry Unit David Meyers (dmeyers7@jhmi.edu , 410-502-4804)Small molecule synthesis, supports structure-activity relationship studiesDrug Screening Library Unit Jun Liu (joliu@jhu.edu, 410-955-4619)FDA approved drug library; repurposing licensed drugs
7. TLC LaboratoriesDrug Development Resources & Services (Continued)Johns Hopkins Drug Discovery Research Consultancy and Services Barbara Slusher (bslusher@jhmi.edu, 410-614-0662)Offers consultants based on 18 years of Pharma industry experience. The program has interactions and connections with the pharma, biotech and venture community.Medicinal Chemistry Unit: Takashi TsukamotoAssay development Unit: Camilo RojasDrug Metabolism & Pharmacokinetics Unit: Rana RaisIn vivo Pharmacology Unit: Krystyna WozniakDrug Development Unit Craig Hendrix (chendrix@jhmi.edu, 410-955-9707)Consultative support for early clinical drug developmentProtocol design, data analysis, clinical study support
8. TLC LaboratoriesBiologics Vic Lemas, Ruth Karron (mvlemas@jhmi.edu , 410-614-5411, rkarron1@jhu.edu, 410-614-0319)Biologic product development/testing, GMP cell lines, gene vectors, antibodies, peptidesProteomics Robert Cole (rcole@jhmi.edu, 410-614-6968)Profiling for small molecules, biomarker development, protein analysisMetabolomics Anne Le (annele@jhmi.edu, 410-955-9297)Analysis of endogenous small molecules, targeted mass spec-based metabolomicsGenetics Garry Cutting (gcutting@jhmi.edu, 410-955-1773)Genetic based sequencing and diagnostic assays, Clinical assay developmentImaging Kasia Macura (kmacura@jhmi.edu, 410-955-6500)Facilitates integrated use of imaging resources, image data file storage, & distributionCRU Core Laboratory Neal Fedarko (ndarko@jhmi.edu, 410-550-2632)Kit-based assays validated, applied to support clinical studies
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10. On The Web - Informationhttp://ictr.johnshopkins.eduClick on Laboratory Services