PPT-Targeted therapies against Acute Myeloid Leukemia

Hiba El Hajj PhD Assistant Professor Departments of Internal Medicine AND Experimental Pathology Immunology and Microbiology Faculty of Medicine American University of Beirut 1 LOREALUNESCO. Farhad. . Ravandi. , . MD. Professor of Medicine. University of Texas MD Anderson Cancer Center. Disclosure of Conflicts of Interest. Dr. . Ravandi. discloses that he is a consultant/advisor for Pfizer, . Ross . L. Levine M.D.. Human Oncology and Pathogenesis Program. Leukemia Service, Department of Medicine. Memorial Sloan Kettering Cancer Center. Weill Cornell School of Medicine. Acute Myeloid Leukemia . Rebecca L. King, . Gerald Wertheim, Michele E. Paessler. The Children’s Hospital of Philadelphia. Perelman School of Medicine at the University of Pennsylvania. Philadelphia, PA. Clinical History. 13 year old boy. Shira . Dinner, MD. Northwestern University. Educational Objectives. Define terminology used regarding leukemia. Describe . the latest developments in . the treatment of acute . lymphoblastic leukemia (ALL). Dr. . B.V.Vydehi. M.D. PROFESSOR OF PATHOLOGY. NARAYANA MEDICAL COLLEGE,NELLORE. Uncontrolled & abnormal proliferation of one of white blood cells & their precursors in the bone marrow and peripheral blood. Justyna Rybka. Department of . Haematology. , Blood Neoplasms and Bone Marrow Transplantation. Wroclaw Medical University. Klinika Hematologii, Nowotworów Krwi. i Transplantacji Szpiku . AML is a heterogeneous haematological malignancy of the myeloid blood cells. PROGNOSTIC FACTORS. Although the first published reports of leukemia occurred in 1845 by Bennett and Virchow, the lack of refined diagnostic methodology limited the distinction between myeloid and lymphoid acute leukemia, With the development of refined staining techniques, followed by microscopy and histochemical staining by the mid-20th century, this distinction was . ental College (JIMDC); 201 3 ;2 ( 4 ): 58 - 63 58 Original Article Acute Myeloid Leukemia amongst Adults Naghmi Asif 1 and Khalid Hassan 2 1 Assistant Professor, Department of Pathology, Islamabad Me Acute Myeloid Leukemia: A Review ARI PELCOVITS, MD; RABIN NIROULA, MD ABSTRACT Acute myeloid leukemia (AML) is a malignancy of the stem cell precursors of the myeloid lineage (red blood cells, pla Medical Science Erythroleukemia with Complex Cytogenetic Abnormalities: A case report with review of literature Pooja K SureshPurnima S RaoUrmila N KhadilkarDepartment of Pathology, Kasturba Medical C Sofia Kolovich. 1. , Allison LaRocco. 1. , . Malith. Karunasiri. 1. , Girish Rajgolikar. 1. , Allison Walker. 1. , Ramiro Garzon. 1. , Marius Bill. 1. , Adrienne Dorrance. 1. . 1. The Ohio State University Comprehensive Cancer Center, Division of Hematology, The Ohio State University, Columbus, OH 43210.. Goals. Incidence. Etiology. Diagnosis. Types/Classification. Treatment. Primary Care Pearls. Incidence. 30% of all cancers in childhood. Peak incidence 2-5 years of age. males > females. Caucasian > African American. . A. ccumulation of abnormal blasts (. I. mmature precursors of WBC). . in bone marrow and blood leading to:. . 1- Bone marrow failure. . (. anemia ,neutropenia & thrombocytopenia). . 2- Organ infiltration . Jayllex Mills,. PharmD Candidate. AML Background. Hematologic malignancy affecting the blood and bone marrow. Result of proliferation of abnormal myeloid stem cell derivatives and interference of normal blood cell production.