Paul C Tsang Molecular Cellular and Biomedical Sciences PRESENTATION OUTLINE The Ovary Follicle Corpus Luteum The Vasculature of the Ovary Angiogenesis formation of new blood vessels Our work on the cow corpus luteum ID: 703799
Download Presentation The PPT/PDF document "CONTRIBUTIONS OF THE OVARY TO FERTILITY ..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
CONTRIBUTIONS OF THE OVARY TO FERTILITY IN DAIRY COWS
Paul C. Tsang
Molecular
, Cellular and Biomedical SciencesSlide2
PRESENTATION OUTLINE
The OvaryFollicleCorpus LuteumThe Vasculature of the OvaryAngiogenesis- formation of new blood vessels
Our work on the cow corpus luteumOur work on the cow follicle
Future directionsSlide3
REPRODUCTIVE PERFORMANCE IN DAIRY COWS
Our focus is:Maternal fertilityCompetent eggOptimal environment in oviduct
Optimal environment in uterusSlide4
VASCULAR TREE OF FEMALE REPRODUCTIVE TRACT
Ginther
; Tanabe; Animal Science Image GallerySlide5
OVARY
FOLLICLE AND CORPUS LUTEUM
Cairodar.comSlide6
OVARIAN FOLLICLES
Nadis.org.uk; ansci.wisc.eduSlide7
OVARY
FOLLICLE AND CORPUS LUTEUM
Cairodar.comSlide8
STAGES OF CORPUS LUTEUM DEVELOPMENT
Fields and Fields, 1996Slide9
ANGIOGENESIS: FORMATION OF NEW BLOOD VESSELS Slide10
theca-derived
luteal cell
granulosa-derived
luteal cell
theca cells
granulosa cells
blood vessels
basement
membrane
Ovulation and Corpus Luteum FormationSlide11
ANGIOGENESIS: FORMATION OF NEW BLOOD VESSELS
LUTEAL CELLSSlide12
STAGES OF CORPUS LUTEUM DEVELOPMENT
Fields and Fields, 1996Slide13
BOVINE CORPUS
LUTEUM PRODUCES MMPS
Goldberg et al. 1996Slide14
MMP2 LOCALIZED TO BOVINE LUTEAL CELLS
Zhang et al. 2005Slide15
ANGIOGENESIS: FORMATION OF NEW BLOOD VESSELS
LUTEAL
CELLSSlide16
CYR61
Cysteine Rich Protein 61ECM-associated signaling proteinImplicated in diverse cellular processes
AdhesionMigration
Proliferation SurvivalAngiogenesisSlide17
BOVINE CORPUS LUTEUM PRODUCES CYR61
Zhang et al. 2011Slide18
theca-derived
luteal cell
granulosa-derived
luteal cell
theca cells
granulosa cells
blood vessels
basement
membrane
Ovulation and Corpus Luteum FormationSlide19
ANGIOGENESIS: FORMATION OF NEW BLOOD VESSELS
FOLLICLE CELLSSlide20
BOVINE GRANULOSA AND THECA PRODUCE MMP2Slide21
ANGIOGENESIS: FORMATION OF NEW BLOOD VESSELS
FOLLICLE
CELLSSlide22
BOVINE GRANULOSA AND THECA CELLS PRODUCE GROWTH FACTORSSlide23
BOVINE GRANULOSA AND THECA PRODUCE CYR61Slide24
SUMMARY: WHAT WE KNOW
Berisha and Schams 2005
CYR61
CYR61Slide25
FUTURE DIRECTIONS:
WHAT WE DON’T KNOW YET
WHAT ARE FACTORS DRIVING THE PRODUCTION OF CYR61 AND OTHER ANGIOGENIC FACTORS IN THE COW FOLLICLE AND CORPUS LUTEUM?Slide26
FUTURE DIRECTIONS
Berisha and Schams 2005
CYR61
CYR61
?
?Slide27
FUTURE DIRECTIONS:
OUR GOAL
WHAT ARE FACTORS DRIVING THE PRODUCTION OF CYR61 AND OTHER ANGIOGENIC FACTORS IN THE COW FOLLICLE AND CORPUS LUTEUM?
DETERMINE A GENETIC ANGIOGENIC SIGNATURE FOR FERTILITY?Slide28
THANK YOU
CURRENT LAB:CHRIS CUMMINGS
JOEY MISEIRVITCH
COLLABORATORS:MARSHA MOSESCHRISTINE COTICCHIADAVID TOWNSON
PAST LAB:MATT GOLDBERGTERESA TOWLEBO ZHANGFACILITIES & FUNDINGFAIRCHILD TEACHING AND RESEARCH CENTER
NH AGRICULTURAL EXPERIMENT STATION- NORTHEAST MULTISTATE PROJECTS NE1027, 1227