PLASMA PROTEINS - PowerPoint Presentation

PLASMA PROTEINS
PLASMA PROTEINS

PLASMA PROTEINS - Description


Introduction Plasma proteins are Serum albumin Serum globulin Fibrinogen Serum contains albumin and globulin Fibrinogen is absent Converted into fibrin during blood clotting Therefore albumin and globulin are called serum albumin and serum globulin ID: 205706 Download Presentation

Tags

proteins blood globulin plasma blood proteins plasma globulin albumin role pressure serum fibrinogen cells protein antibodies liver procedure rbcs

Embed / Share - PLASMA PROTEINS


Presentation on theme: "PLASMA PROTEINS"— Presentation transcript


Slide1

PLASMA PROTEINSSlide2

Introduction:

Plasma proteins are:

Serum albumin.

Serum globulin.

Fibrinogen.

Serum contains albumin and globulin.

Fibrinogen is absent

Converted into fibrin during blood clotting.

Therefore albumin and globulin are called serum albumin and serum globulin.Slide3

Normal values:

Total proteins: 7.3 g/

dL

Serum albumin : 4.7 g/

dL

Serum globulin : 2.3 g/

dL

Fibrinogen : 0.3 g/

dL

Albumin/ globulin ratio:

Important indicator of diseases involving liver or kidney.

Nomal

A/G ratio is 2:1.Slide4

Origin of plasma proteins:

In embryo:

Mesenchyme

cells.

1

st

: albumin. Others synthesized later.

In adults:

Reticuloendothelial

cells of liver.

Also from spleen, bone marrow, disintegrating blood cells and general tissue cells.

Gamma globulin is synthesized from B lymphocytes. Slide5

Properties of plasma proteins:

Molecular weight:

Albumin: 69,000

Globulin: 1,56,000

Fibrinogen: 4,00,000

Oncotic

pressure:

Responsible for osmotic pressure in blood.

Colloidal osmotic pressure.

25 mm Hg.

Specific gravity:

1.026.

Buffer action:

Acceptance of hydrogen ions.

1/6 of total buffering action.Slide6

Functions of plasma proteins:

1.

ROLE IN COAGULATION OF BLOOD:

Fibrinogen is essential for coagulation.

2.

ROLE IN DEFENCE MECHANISM:

Gamma globulins acts as antibodies.

Immunoglobulins

.

3.

ROLE IN TRANSPORT MECHANISM:

Albumin, alpha globulin and beta globulin are responsible for transport of hormones, enzymes, etc.

Alpha and beta globulins play an important role in transport of metals in blood.

4.

ROLE IN MAINTENANCE OF OSMOTIC PRESSURE IN BLOOD:

Plasma proteins can’t pass through capillary membranes and remain in blood.

They exert osmotic pressure of 25 mmHg.

Albumin exerts maximum pressure.

Starling hypothesis: net filtration through capillaries is proportional to hydrostatic pressure difference minus

oncotic

pressure difference. Slide7

5.

ROLE IN REGULATION OF ACID BASE BALANCE:

Ability of proteins to take up hydrogen ions.

6

.

ROLE IN VISCOSITY OF BLOOD:

Provide viscosity to maintain blood pressure.

7

.

ROLE IN ERYTHROCYTE SEDEMENTATION RATE:

Globulin and fibrinogen accelerate the tendency of

rouleax

formation by RBCs.

8

.

ROLE IN SUSPENSION STABILITY OF RBCs:

Globulin and fibrinogen helps in suspension stability of RBCs.

9. ROLE IN PRODUCTION OF TREPHONE SUBSTANCES:

Produced by leukocytes from plasma proteins.

10. ROLE AS RESERVE PROTEINS:

Used as source of energy. Plasma proteins are split into amino acids by tissue macrophages. Amino acids are taken back by blood and distributed throughout the body to form cellular protein molecules. Slide8

PLASMAPHERESIS:

Experimental procedure done in animals to demonstrate the importance of plasma proteins.

Also called

whipple’s

experiment.

Procedure:

Demonstrated in dogs. Blood is removed completely from body.

RBCs are separated from plasma, washed with saline and

reinfused

into the body of same dog along with

locke’s

solution.

Sudden lack of proteins results in state of shock.

High protein diet results in restoration of proteins in 7 days. New plasma proteins are synthesized by liver of dogs.

High protein diet after removal of liver-> plasma proteins are not produced.

Persistant

shock

results in death.Slide9

Plasmapheresis demonstrates:

Importance of plasma proteins for survival.

Synthesis of plasma proteins by liver.Slide10

Clinical significance:

Blood purification procedure.

Effective for temporary treatment of autoimmune diseases.

Immune system attacks body’s own tissues.

Antibodies are protein in nature that circulate in the blood before attacking tissues.

Plasmapheresis removes these antibodies from blood.

Also called therapeutic plasma exchange.Slide11

Procedure:

Venous blood removed.

Blood cells are separated from plasma by cell separator.

Anticoagulant prevents clotting of blood.

After removal. Plasma is discarded and cells are returned cells are returned to blood stream by mixing with saline and sterilized human albumin protein.Slide12

Uses of

plasmapheresis

:

Used to remove antibodies from blood.

Temporary benefit of protecting the tissues from antibodies.

Required repetitive session of the treatment.

Diseases:

Mysthenia

gravis.

Thrombocytopenia

purpura

.

Paraproteinimic peripheral neuropathy.

Chronic demylenating polyneuropathy.

Guillain

barre

syndrome.

Lambert Eaton

myasthenic

syndrome.Slide13

Shom More....
trish-goza
By: trish-goza
Views: 173
Type: Public

Download Section

Please download the presentation from below link :


Download Presentation - The PPT/PDF document "PLASMA PROTEINS" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.

Try DocSlides online tool for compressing your PDF Files Try Now