PPT-SMAD4: a Tumor Suppressor Implicated in Juvenile Polyposis

Smad4 is a key part of TGF beta signaling pathway Inhibits epithelial cell growth SMAD4 is a tumor suppressor that was discovered in association with pancreatic cancer De Bosscher et al . NADIR R. FARID INTRODUCTION Most tumor suppressor genes (whose function in cancer biology was surmised by their inactivation or deletion) turn out to be important in normal cell growth and Christopher H. . Crane. , M.D.. Professor. Program Director and Section Chief, Gastrointestinal Section. Department of Radiation . Oncology. No Disclosures. Why is pancreatic cancer a bad disease?. - The Hippo pathway is one of many tumor suppressor pathways that is used to control the growth of tissues and organs. The founding members of the pathway were discovered by Georg Halder and . Iswar. DNA pol error rate . ~. 10. -9. per base . copied. How many errors in a . “typical” . somatic cell?. Most errors don’t have detectable effects. But some errors do: . . oncogenes. N. . – dominant. AAAAADMw/z-P-qGQqskQ/s640/. RedLightGreenLight1. .jpg. 1. Red Light. , . Green Light. !. Contributors. Melanie Badtke Regis University. Amanda Charlesworth University of Colorado, Denver. Melissa Krebs Colorado School of Mines. PATHG4500 Fall 2019. Introduction. Recommended Textbook . The Biology of CANCER. Robert A. Weinberg. Second Edition. Cancer Biology PATHG4500-001. Meets on select Mondays and Wednesdays. Course Directors: Anna . Mary McCullum, RN, MSN, CON(C). Nurse Educator, Hereditary Cancer Program. BC Cancer Agency. September 22, 2017. Objectives. Identify hereditary polyposis syndromes. Review hereditary cancer/polyposis referral process. LEC.4. Examples of tumor suppressor genes:. 1. RB gene:. This is the . first discovered suppressor gene. , . loss of normal RB gene was discovered initially in Retinoblastoma, but recently proved it lost in many tumors (breast cancer, bladder & lung cancer, osteosarcoma).. Marco Novelli FAP, MAP, NAP and PPAP Marco Novelli Overview • History of polyposis • Familial adenomatous polyposis • MYH - associated polyposis • NTLH1 - associated polyposis • Other polypo An Introduction to MUTYH Associated Polyposis(MAP)ContentsWhat is MUTYH Associated Polyposis (MAP)? What causes MUTYH Associated Polyposis (MAP)? 3 How is MAP inherited? 4 enetic Testing 5 ow is MAP m Catalog Num.Antibody TypeDilutionVolume/Qty Intended Use For In Vitro Diagnostic Use.This antibody is intended for use in Immunohistochemical applications on formalin-xed paran-embedded t Version 10 Contact details Regional Genetics Service Levels 4 - 6, Barclay House 37 Queen Square London, WC1N 3BH T +44 (0) 20 7762 6888 F +44 (0) 20 7813 8 578 Samples required  Tumour testing: . Introduction. Tumor. . can be benign, pre-malignant, or malignant, whereas . cancer. is by definition malignant.. Cancer. . is a group of diseases characterized by . unregulated cell growth . and the . Cancer terminology. Classification by tissue type:. carcinoma. epithelial cell. 90% of all tumours. derived from . ectoderm . (mostly) or . endoderm . (some). sarcoma. connective tissue. 2% of all tumours.