PPT-ANTIPLATELET DRUGS Activation of platelets is considered an essential process for arterial

Physiologically when platelets are activated they undergo a sequence of reactions that are essential for hemostasis amp important for the healing of damaged blood vessels These reactions include. Antiplatelet Guidelines. Antiplatelet. Therapy for . Vascular Prevention in Patients with Peripheral Arterial Disease. Working. Group. : A. Roussin, MD, FRCP; Thomas F. Lindsay, MD, CM. , FRCSC. Objectives. Tx. : . Real-World Practice. In the US, ~800,000 AF patients are on concomitant OAC and antiplatelet tx. 1. Patients on chronic OAC with CAD are 7x more likely to receive concomitant antiplatelet tx. Thrombocytes. Platelets (Thrombocytes). 2- 4 micromillimeters in diameter. 250,000 – 400,000 per microliter . (too few thrombocytopenia – too many thrombocytosis). Lifespan on average 6 – 10 days. Thrombocytes. Platelets (Thrombocytes). 2- 4 micromillimeters in diameter. 250,000 – 400,000 per microliter . (too few thrombocytopenia – too many thrombocytosis). Lifespan on average 6 – 10 days. Today’s Information. Why the need for essential oils NOW?. What essential oils do compared to drugs. How to implement into practice seamlessly. How to attract new patients with MCM and DIY classes. the Hemostatic System During. Cardiopulmonary Bypass. Normal hemostasis. circulating platelets adhere to the . subendothelium. that is exposed when the . vascular lining . is broken. .. . Adhesion of platelets to the endothelial bed is mediated . Minilecture. Objectives. Indications for Antiplatelet Therapy in patients with CAD and ACS. Antiplatelet Therapy in the role of primary and secondary prevention of . c. ardiovascular events. CAD & the Vulnerable Plaque. : the smallest of the formed elements in blood, a disk-shaped, non-nucleated blood element with a fragile membrane, formed in the red bone marrow by fragmentation of . megakaryocytes. . Platelets tend to adhere to uneven or damaged surfaces, and there are an average of about 250,000 per mm. thrombocytopenia. ) constitutes an important cause of generalized bleeding.. A count less than 100,000 platelets/. μL. is generally considered to constitute thrombocytopenia. . Platelet counts in the range of 20,000 to 50,000 platelets/. Anticoagulant therapy. (n = . 124). CADISS. P. rimary outcome. : . Ipsilateral . stroke or all-cause mortality . for antiplatelet vs. anticoagulation: 2. % . vs. 1%; p . = . 0.63. Any stroke: 2% vs. 1%, . Gilead Sciences. Foster City, CA , USA. Activating. PKC-. ε . induces HIV. expression with improved tolerability. This study was funded by Gilead Sciences, USA. Protein Kinase C(PKC) agonists activate latent HIV, but have limited clinical utility due to toxicity. . Dr. Tariq Aladily. Associate professor. Department of Pathology. The University of Jordan. tnaladily@ju.edu.jo. Abnormal bleeding. Defined as spontaneous bleeding or prolonged bleeding after trauma. Caused by abnormality in:. Ishfaq. . Bukhari. Dec. 2012. In healthy vasculature, circulating platelets are maintained in an inactive state by nitric oxide (NO) and . prostacyclinre. (PGI2)leased by endothelial cells lining the blood vessels.. intracerebral haemorrhage (ICH): extended follow-up of the. RE. start. or . ST. op. . A. ntithrombotics. . R. andomised . T. rial. (RESTART) . RESTART Collaboration. www.RESTARTtrial.org. Intracerebral haemorrhage (ICH) is associated with an increased risk of arterial ischaemic events*: pooled analysis of 4 population-based cohorts.