ADVERSE DRUG REACTIONS : IDENTIFICATION,

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ADVERSE DRUG REACTIONS : IDENTIFICATION, MANAGEMENT AND REPORTING SYSTEM Prof. Rakesh Kumar Tewari, M.D.(Ay.) I.M.S.(BHU), Head, Deptt Of Dravyaguna, R.A.M.C.H, Bareilly (UP). E mail : vdrakesh.tiwarigmail.com IMPORTANCE OF KNOWING ADRs

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ADVERSE DRUG REACTIONS : IDENTIFICATION, MANAGEMENT AND REPORTING SYSTEM Prof. Rakesh Kumar Tewari, M.D.(Ay.) I.M.S.(BHU),
Head, Deptt Of Dravyaguna,
R.A.M.C.H, Bareilly (UP).

E mail : vdrakesh.tiwari@gmail.com<br>
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IMPORTANCE OF KNOWING ADRs Although in public opinion ASU Drugs are considered to be natural, safe, harmless, risk free, can be used without medical supervision, virtually for effective and safe drug therapy it is important to know :-
Nature and severity of ADR.
Whether treatment has to be stopped or not?
How safe the drug is?
How it may be made more safe and acceptable to patient?<br>
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MEASURE OF SAFETY: THERAPEUTIC INDEX (T. I.) T.I. = LD 50 (Median lethal dose ) ED 50 ( Median effective dose ) Drugs with a T.I. of : 10 or more - safe. 3 or 4
< 3 must be used cautiously.
cannot be used safely . Note: - clinical T.I. for same drug may be different in different situation e.g. T.I. for Aspirin in headache is more than its T.I. for Antiarthritic and Antirheumatic uses (dose 0.3 to 1g / day as compared to 5 to 10g/day respectively).<br>