Dynamic Display of Bioactivity for Regenerative

marina-yarberry
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Dynamic Display of Bioactivity for Regenerative
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Dynamic Display of Bioactivity for Regenerative Medicine Challenge: Regenerative medicine by stem cells is potential solution for tissue repair However, regeneration is complex - cellular responses change over: Time attachment

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Dynamic Display of Bioactivity for Regenerative Medicine Challenge:
Regenerative medicine by stem cells is potential solution for tissue repair
However, regeneration is complex - cellular responses change over:
Time attachment → proliferation → differentiation
Space bone, nerve, skin differentiation within one tissue
Develop ECM with dynamic spatio-temporal control over epitope display

Dynamic alginate-cyclodextrin surface with dynamic host-guest chemistry:
Allows for dynamic spatio-temporal manipulation of cell activities
Time stepwise exchange of biochemical cues (epitopes) can direct cell activity
Space surface patterns direct cell growth

Surface is functionalizable




Surface can be patterned Ellen Zhuang | The Stupp Group<br>