Parkinson’s disease Levodopa Levodopa (L-dopa) is

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Parkinson’s disease Levodopa Levodopa (L-dopa) is
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Parkinsons disease Levodopa Levodopa (L-dopa) is the naturally occurring L-isomer of the amino acid dihydroxy- phenylalanine (an isomer is a chemical with the same formula but a 3-dimensionally different structure)1 Levodopa is

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Parkinson’s disease Levodopa Levodopa (L-dopa) is the naturally occurring ‘L-isomer’ of the amino acid dihydroxy- phenylalanine (an isomer is a chemical with the same formula but a 3-dimensionally different structure)1
Levodopa is transported into the brain across the blood–brain barrier, where it is the precursor to several neurotransmitters, including dopamine2
To preserve levodopa for the brain, by preventing the conversion of levodopa to dopamine outside the brain (which may be associated with peripheral dopaminergic effects such as nausea and vomiting), levodopa is prescribed with a ‘peripheral’ dopa decarboxylase inhibitor2,3 1. Hornykiewicz. J Neurol 2010;257(Suppl 2):S249–252; 2. Wolters & Baumann. Parkinson Disease and Other Movement Disorders. 2014; 3. Jankovic & Aguilar. Neuropsychiatr Dis Treat 2008;4(4):743–757; 4. Trenkwalder et al. Neurology 2019;92(13):e1487–e1496 1 Levodopa, once converted to dopamine in the brain, increases the levels of dopamine, counteracting the pathologically low levels of the neurotransmitter in the PD brain1,2,4
Levodopa treatment needs to be tailored to the needs of the individual patient3<br>