PPT-Tissue‐specific genotype–phenotype correlations among USH2A‐related disorders in

Presented on behalf of the foundation fighting blindness consortium investigator group Outline Background Study Design Participants and Methods Results Discussion Background USH2A Biallelic diseasecausing variants in . Correlation Objectives i Calculate correlations i Calculate correlations for subgroups using split file i Create scatterplots with lines of best fit for subgroups and multiple correlations Correlation The first infer Incomplete Dominance. One allele is not completely dominant over the other.. The heterozygous phenotype is . in-between. . the homozygous phenotypes.. Incomplete Dominance. If you cross a . RED. flower with a . Pasring. Reporters: R98922004 . Yun-Nung. Chen,. R98922033 Yu-Cheng Liu. Reference. Ming Actor Correlations with Hierarchical Concurrence Parsing (ICASSP 2010). Kun Yuan, . Hongxun. Review. Why is genetics important?. Genetics. -the study of how genes bring about characteristics (traits) in living things and how those traits are inherited . Genes. Portions of DNA molecules that determine characteristics of living things. Genetics = the study of . HEREDITY. Heredity = Passing of . Traits. from parents to offspring. Predicted how . TRAITS. are transferred from one generation to the next. Father of Genetics. Gregor. Mendel, an Austrian monk is known as the FATHER of GENETICS.. Pasring. Reporters: R98922004 . Yun-Nung. Chen,. R98922033 Yu-Cheng Liu. Reference. Ming Actor Correlations with Hierarchical Concurrence Parsing (ICASSP 2010). Kun Yuan, . Hongxun. 1. http://curation.phi-base.org/. 2. Data capture models. Canto captures data like this:. gene -> gene annotation -> annotation extensions (for additional annotation detail). PHI-Canto has been adapted from Canto for . . Inheritance. . Review. . Incomplete. . Inheritance. Co-dominance. . Inheritance. SBI3U. •. . When. . one. . (1). . allele. . is. . stronger. . (so. . dominant). . than. . the. . Michael Nethercutt, 2017. Subjects = Students at ECU. Sex. Spirituality. Receptivity to Pseudo-Profound Bullshit. http://. journal.sjdm.org/15/15923a/jdm15923a.pdf. . Bullshit Receptivity and Politics. Pre 1800s – blending hypothesis. 1850s – Gregor Mendel. Pisum. . sativum. . – what makes pea good genetic model?. -. -. -. -. Pea character (gene) = . Pea trait (allele) = . self fertilization . Slide 1/26ACM SOSP 2007Presented byIgnacio LagunaSlide 2/26Semanticand ConcurrencybugsTwo of the most difficult to detectVariable Access Correlationscan be exploited to detect these bugsMany variables Most genes are carried on the ___________, ______ chromosomes other than the sex chromosomes. These disorders affect males and females ________ and are due to _____ mutations. Autosomal disorders can be divided into three groups based on the pattern of inheritance.. Sample & Methods. . 100 index cases (IC): 87 adults and 13 children; 8 were severe forms. . Identifies variants were traced in 36 relatives. NGS panel: LDLR, APOB, PCSK9, LDLRAP1 and APOE . (. Review 8. Important Vocabulary. Gene – piece of a chromosome that codes for a trait. Trait – a specific characteristic that varies from one individual to another. You are your parents!. Dad’s chromosomes.