PPT-Genetic Association Analysis

Clement Ma Sequence Analysis Workshop May 21 2015 Lecture slides adapted from Hyun Min Kang and Gonçalo Abecasis Outline Introduction Data overview Analysis of common variants Analysis of lowfrequency variants. Pattern Analysis. Finding patterns among objects on which two or more independent variables have been measured. . Principal Coordinates Analysis . (PCO). Principal . Components Analysis. . (PCA) (. Lecture 1: Introduction. Linkage studies. Traditional approach to identifying genes for human traits and diseases was through linkage.. For . Mendelian. diseases (e.g. Huntington’s disease) there is a clear co-segregation of genetic markers with disease within pedigrees.. Ideas in . Gattaca. Vocabulary. Look out for new vocabulary in this presentation that will be useful to use in your essays – it will be . coloured. . red. What is . Eugenics. ?. The . study of or belief in . Risks and Benefits of Knowing Your Genetic Makeup. Julie Hopp. Genetic Screening: Who Should Be Tested. CDC’s 2004 Science Ambassador Program. Overview. Genetics Review. Types of Genetic Disorders. You can compare dogs of every breed imaginable! . There is an enormous range of characteristics that are the result of . genetic variation. . . The differences among breeds of dogs are so great that someone might think that many of these breeds are different species. . Population and family based association study on TPH1, TPH2 and ITGB3 genes indicate serotonergic system involvement in autism spectrum disorder Asem Surindro Singh, Ph. D. Email: asemsuren@gmail.com Nelson Freimer. UCLA Center for Neurobehavioral Genetics . What makes a genetic association significant?. Outline. The problem of achieving validated findings in psychiatric genetics. Approaches to genetic mapping and statistical significance. Lucia . Colodro. Conde, Elizabeth Prom-Wormley, and Hermine . Maes. . with thanks to . Meike. Bartels and . Dorret. . Boomsma. In . \\workshop\Faculty\lucia\Wednesday_biv_practical. , Open twoACE_vc_nl_biv_2gr.R. Polydactyly. Down Syndrome. Hemophelia. Progeria. Hypertrichosis. Sickle Cell Anaemia. INTRODUCTION. What is genetic diseases/disorders?. The human body is composed up of cells , each one specializing a particular function like sensing light, smelling . What is the difference between . the mice in these two groups?. What is genetic engineering?. Genetic engineering is the . direct modification of an organism’s genome. , which is the list of specific traits (genes) stored in the DNA. . Kesheng Wang, PhD. Department of Biostatistics and Epidemiology. College of Public Health. East Tennessee State University. 2. Outline. Introduction . Alcohol dependence (AD). Genetic study. . Subjects and Methods. 25.05.12. 1. Angelina Fahmay . AZT Case study. 1) Involving 100mg AZT. :. 24 healthy subjects. (12 Female, 12 Male) . Weights of healthy subjects (Range: 50-77kg) (Average: 62kg) . Given . FOUR different . ?. G. enetic . engineering. , the artificial manipulation, modification, and recombination of DNA or other nucleic acid molecules in order to modify an organism or population of organisms. . This . may mean changing one base . Suud. . khalifa. 2- Diseases caused by mutation in mitochondrial genes:. Mitochondria contain several genes encodes for enzymes of oxidative phosphorylation, usually the ovum contain the large part of mitochondria, so the inheritance of mitochondrial gene is maternal..