PPT-Asymptomatic plasma cell dyscrasias –Smoldering myeloma & MGUS

Aric Hall MD Assistant Professor UW Health Objectives To discuss pathophysiology of plasma cell disorders To define and describe the asymptomatic plasma cell dyscrasias To discuss prognosis. Round Cell Tumors. Wendy Blount, DVM. Round Cell Tumors. Lymphoma. Mast Cell Tumor. Plasma Cell Tumor. Extramedullary Plasmacytoma. Multiple myeloma . Histiocytic Disease. Transmissible Venereal Tumor. Paul Moss. Birmingham, UK. Outline. Introduction to immunotherapy. Immunotherapy in the setting of Myeloma . Cellular therapy. Future application. History of Cancer Therapy. Surgery. 1000s of years. Radiotherapy. NICE Guideline. Published Feb 2016. Adults with myeloma (and plasma cell leukaemia). Excluded:. Monoclonal . gammopathy. of uncertain significance (MGUS). Amyloidosis. Solitary . plasmacytomas. Included:. Presented By Sham Mailankody at 2016 ASCO Annual Meeting. Massive genetic heterogeneity in <br />multiple myeloma. Presented By Sham Mailankody at 2016 ASCO Annual Meeting. Multiple myeloma consistently preceded by precursor states. Smoldering Myeloma: To Treat or not to Treat Ruben Niesvizky MD Myeloma Center Myelomacenter.org run9001@med.cornell.edu CASE A 47-year-old man is diagnosed with smoldering multiple myeloma . He has Starr Morning Report Austin Akers, MD Internal Medicine PGY-3 Patient is a 59 year old previously fit and active male in remarkably good health for his age who has experienced a rapid overall physical decline over the last 2-3 months Vi Dao, MD, FRCPC. vdao@cancercare.mb.ca. Presenter Disclosure. Faculty: Vi Dao. Relationships with commercial interests: none. Mitigating Potential Bias. Not Applicable. Learning Objectives. Distinguish MGUS from multiple myeloma. Can we do better?. [Hospital name]. [Date]. What is myeloma?. Cancer of plasma cells. Leads to:. Bone infiltration. - fractures (especially vertebral wedge fractures), hypercalcaemia. - pain. Professor Mark Drayson, University of Birmingham. 13. th. March 2019. Distinguishing myeloma from MGUS by m-protein and serum free light chain results alone. M. yeloma . is the worst cancer for delayed diagnosis . MULTIPLE MYELOMA AND LABORATORY VALUES Benjamin Parsons, DO bmparson@gundersenhealth.org Gundersen Health System Center for Cancer and Blood Disorders La Crosse, WI Multiple Myeloma is a cancer of Plasma cell dyscrasias are diseases characterized by clonal proliferation and accumulation of cells producing monoclonal immunoglobulins. These diseases have not been studied in our region and we don Myeloma Symposium 9/29/2018. Aric Hall, MD – Assistant Professor – UW School of Medicine & Public Health. Disclosures. I have no significant conflicts of interest to disclose. . I have no financial relationship with any institution profiting from pharmaceutical sales, diagnostic testing, or any type of medical technology. . Risk stratification and Therapeutic Options. Natalie S. Callander, M.D.. University of Wisconsin Carbone Cancer Center. 1. MGUS definition. 2. Factors associated with MGUS progression. 3. Appropriate evaluation. Grace B. Athas, Ph.D. . MLS. Department of pathology, LSUHSC. CLPC Spring seminar series, 2018 . Learning objectives. Review pathophysiology and lab diagnosis of plasma cell neoplasms with a focus on Multiple Myeloma.