PPT-In vivo preclinical activity

of MGD014 and MGD020 HIV1 envelope x CD3 DART molecules and firstinhuman phase 1 clinical safety evaluation of MGD014 Shake and bake Promising strategies for HIV cure JL Nordstrom 1 CL Gay. Animal Models. Steven Perrin, PhD. CEO, CSO. ALS Therapy Development Institute. Historical Issue with Pre-clinical Animal Model Development and Validation . Optimized Experimental Design for Preclinical Drug Screening in the ALS Mouse Model, 2007. Mike Conlon, Nicholas Rejack and Laura . Guazzelli. UF Clinical . and Translational Science Institute, University of Florida. Why Python?. Python and VIVO. Useful Libraries. References. Python. 1,2 . Presented to the. National . Association of Agricultural Economics . Administrators. Sept. 9, 2011. by. Robbin Shoemaker, NIFA. NIFA Update. Search continues for new Director. Chavonda Jacobs Young is Acting Director. be cleared by CTL . ?. Una O’. Doherty. June 29, 2013. Infect (X4 or R5 HIV). Culture 3-4d. Measure total & integrated HIV DNA. Our experimental system. O. ’. Doherty U . J. Virol.. 2000. O. in vivo. studies: . validation . protocols; . different markers, triggers, . agents, etc . Need . for . harmonization & standardization of the essential protocols/methodologies . for validation of . Mike Conlon, Nicholas Rejack and Laura . Guazzelli. UF Clinical . and Translational Science Institute, University of Florida. Why Python?. Python and VIVO. Useful Libraries. References. Python. 1,2 . Communities. Han Wang. 1 . (. wangh17@rpi.edu. ). , . Yu Chen. 1 (. cheny18@rpi.edu. ). , Patrick West. 1 (. westp@rpi.edu. ). , John S. Erickson. 1 (. erickj4@rpi.edu. ). , . Xiaogang. Ma. 1 (. max7@rpi.edu. Lecture #42. 1. Outline. Allometry. Microdosing. Predicting Clearance. Absorption, Distribution and . Metabolism. Whole Body Physiological Models. Predicting Pharmacodynamics. Virtual Patient Populations. Comparative Biosciences, Inc.. 786 Lucerne Drive. Sunnyvale, CA 94085. Telephone: 408.738.9260. www.compbio.com. A TRANSLATIONAL APPROACH TO PRECLINICAL RESEARCH. Comparative Biosciences, Inc.. 20 years . Sarepta. Therapeutics. Associate Professor of Medicine, Infectious Diseases. Harvard Medical School/Beth Israel Deaconess Medical Center. Public Health Council. Massachusetts Department of Public Health. Brussels, September 10, 2012. Michael . Conlon, . PhD. Clinical and Translational Science Institute. University of Florida. Learned a field, learned the scientific method, did science. Research Process 1972. Alex Chang, MD, Kelly Cederquist, . MMSc. PA-C, Peter L. Abt, MD, Grace Wang, MD MSCE, Benjamin Jackson, MD, Ali Naji, MD PhD. University of Pennsylvania, Perelman School of Medicine. Penn Transplant Institute. Holznagel E, Yutzy B, Schulz-Schaeffer W, Kruip C, Hahmann U, Bierke P, et al. Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates. Emerg Infect Dis. 2013;19(5):712-720. https://doi.org/10.3201/eid1905.120274. Acronyms used in preclinical . development. Beginners. Brief recall about clinical trials. The Funnel. Road map. Example of drug development: . . Chemical level. . Pharmaceutical level. . Preclinical pharmacology.