PPT-Kinetics of DNA Damage and Repair in Fish using the Zebrafish

Danio rerio as a model Chris A McCabe 1 Chris W Theodorakis 2 Theodore B Henry 1 and Mark G J Hartl 1 Introduction Environmental stressors can damage the DNA of aquatic organisms. Enter CPR® – Cell Phone Repair Franchise Systems, Inc. (CPR®) – an independent service organization dedicated to the on-premises repair of cell phones, iPods, and electronic devices at all of our locations from Yukon, OK, to Los Angeles, CA. Enter CPR® – Cell Phone Repair Franchise Systems, Inc. (CPR®) – an independent service organization dedicated to the on-premises repair of cell phones, iPods, and electronic devices at all of our locations from Yukon, OK, to Los Angeles, CA. . zebrafish. model for inflammatory bowel disease (IBD): preliminary results. Simon Haarder. 1, 3. , Per Kania. 1. , Poul Hyttel. 2. , Thomas . Lindebo. Holm. 3. and Kurt Buchmann. 1. 1 . Nucleotide Excision Repair XP and CS. BiS222. By . Jooyoung. Chang . 장주영. Class #01 / Stu. #20091259. Assembling a Car. An analogy. Steps in building a CAR. Steps in building a . PROTEIN. Q: Most . DNA damage and repair and their role in carcinogenesis. A DNA sequence can be changed by copying errors introduced by DNA polymerase during replication and by environmental agents such as chemical mutagens or radiation. (. Danio. . rerio. ) . as a model. Chris A. . McCabe. 1. , Chris W. Theodorakis. 2. , Theodore B. Henry. 1. and Mark G. J. . Hartl. 1. Introduction . Environmental stressors can damage the DNA of aquatic organisms. Pratt & . Cornely. . Ch. 7. Enzyme Kinetics. How fast an enzyme catalyzed reaction goes. Why study enzyme kinetics?. Helps us understand mechanism of enzyme (how it works). Investigation of mutations in metabolic pathways. Program Overview . Discussion Outline. DNA Repair. ABCs of DNA Repair. DNA Repair Defects in Cancer. DNA Repair Defects Can Be an Achilles' Heel. Synthetic Lethality and Cancer DNA Repair Defects. Increased Sensitivity of . DNA damage DNA gets damaged a lot ! DNA damage DNA gets damaged a lot! >200,000 events/human cell/day DNA damage Occurs 2 ways 1) spontaneously 2) mutagens : damage DNA Transposons Discovered by Barbara McClintock zebrafish. ???. Can house a lot of genetically distinct lines in not a lot of space!. Isolated mutations in hundreds of genes which affect embryonic development. Inherited mutations in some genes predisposes fish – like humans! – to cancer.  . Author: Michael Fenech. Affiliation: Genome Health Foundation, North Brighton, SA, 5048, Australia. Email: . mf.ghf@outlook.com. . Introduction. Life as we know it depends entirely on the capacity of cells to utilize energy and molecules in the environment for cellular function and reproduction. . (Chapter 12). Presented by Dr. Laurie M. Erickson. Chair of the Department of Health Sciences. Blitstein Institute of Hebrew Theological College. Chicago, IL, USA.. 12.1-12.2 Mutations . Mutation:. any heritable change in the genetic material. If we have an error one in a million this mean we will have 3000 errors during each replication cycle of the genome.. The genome of a typical mammalian cell . accumulates many . thousands of lesions during a 24-hour period.. Elise Whitlinger. 1,2. , Madison Rager. 2. , Andrew Kwok-Ping Lam. 2. , Hui Feng. 2. Freeport Area High School, 625 S Pike Road, Sarver, PA 16055. 1. , Boston University School of Medicine, 72 East Concord Street, K-712A Boston, MA 021182.