PPT-Mechanisms of Antimicrobial Resistance

Third Lecture 2022 Assist Prof Mohammed AboKsour It is the ability of microbes to grow and multiply in the presence of antimicrobial agent that would normally kill them or limit their growth The concentration of drug at the site of infection must inhibit the organism and . TKI. s. . and . related. . treatment . strategies. Rafal . Dziadziuszko. Medical. . University. of Gdańsk, Poland. 16th European . Congress. „. Perspectives. in . Lung. Cancer. ” . Torino. N. gonorrhoeae. . A Review. INTRODUCTION. Progressive antimicrobial resistance in . Neisseria gonorrhoeae . is an emerging public health threat. The Public Health Agency of Canada (the Agency) released updated recommendations in July 2013 for the diagnosis, treatment, follow-up and reporting of gonorrhea. . Dr Andrea Ammon, ECDC Director, . 27 June 2017, European Parliament. 0. 200. 400. 600. 800. 1000. 1900. 1920. 1940. 1960. 1980. 2000. 1918. Influenza pandemic. 1924. Plague: last human-to-human transmission. a pharmaceutical industry perspective. 17. th. November 2018. Dr Bryan Deane. Dept of Research, Medical & Innovation . Introduction – the ABPI; the biopharmaceutical industry. AMR: the issue. Antibiotics. Antimicrobial drugs naturally produced by microorganisms. Penicillium. . species: . Penicillins. Cephalosporium. . specis. : . cephalosporins. Streptomyces. . species:. . lincosamides. Copyright © 2015 by Saunders, an imprint of Elsevier Inc.. Introduction. Antimicrobial agents. Chemical compounds to kill or suppress microorganisms. Antibiotics. Natural, semisynthetic, or synthetic molecules used to treat or prevent disease . Insert your organisation’s name here . Insert presenter’s name here . #. worldantimicrobialawarenessweek. Overview. Antibiotics are . vital life-saving . medicines . Antimicrobial resistance is both a global and local problem. Therapy. The development of antimicrobial drugs represents one of the most important advances in therapeutics, both in the control or cure of serious infections and in the prevention and treatment of infectious complications of other therapeutic modalities such as cancer chemotherapy, immunosuppression, and surgery.. Komal. . Pareek. 1. Key Terms. Antibiotic = A drug that kills or inhibits the growth of microorganisms. Resistant = Somewhat arbitrary designation that implies that an antimicrobial will not inhibit bacterial growth at clinically achievable concentrations. . MDR. was defined as acquired . non susceptibility. . to . at least one agent in three or . more antimicrobial . categories. ,. . XDR. was defined as . non susceptibility. . to . at least one agent in all but two or . Consequences of AMR. What can we do ?. Microbiology and the antibiotic apocalypse. Dr Dave Whitworth. dew@aber.ac.uk. Reader in Biochemistry. Microbiology and the antibiotic apocalypse. What are antibiotics ?. Resistance : T ackling a crisis for the health and wealth of nations The Review on Antimicrobial Resistance Chaired by Jim O’Neill December 2014 Contents What is antimicrobial resistance? CC – 14/ UNIT - 7. Azidothymidine Antibiotic Resistance. Zidovudine (AZT). A synthetic pyrimidine (thymidine) analogue. AZT is converted to its triphosphate form by cellular thymidine kinase. It binds preferentially to HIV – reverse transcriptase resulting in chain termination. . 1. 1. Antibacterial resistance in ophthalmic infections: a multi-centre analysis across UK care settings//BMC Infectious Diseases.- volume 19, Article number: 768 (2019) . Educational MODULE. November 2020.