Eric Sobie Mount Sinai David Christini Weill Cornell U01 HL 136297 The model 1 Improved ODE representations of cardiomyocyte electrophysiology and intracellular calcium 2 Statistical models of heterogeneous cell populations ID: 932359
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Slide1
Multiscale modeling to map cardiac electrophysiology between species
Eric Sobie, Mount Sinai
David Christini, Weill Cornell
U01 HL 136297
The model
(1)
Improved ODE representations of
cardiomyocyte
electrophysiology and intracellular calcium
(2) Statistical models of heterogeneous cell populationsWhat is new inside? New methods for tuning parameters and building models specific to individual samplesCombined mechanistic ODE models with statistical, machine learning approaches
Impact
: Improved methods for validating and tuning models, leading to more credible representations
End users: Cardiologists, cardiac physiologists, safety pharmacologists interested in preventing adverse cardiac events