PPT-A Randomised Phase II study of

A ccelerated D ose escalated S equential C hemor a diotherapy in N onSmall Cell Lung Cancer Rationale Lung cancer is the most common cause of cancer mortality in the UK and . C. ontrolled Trials: a workshop. Ngaire. . Kerse. Professor and General Practitioner and asker of questions. . Key issues - . randomised. trials. There must be uncertainty. The question m. ust be answerable and feasible. Graeme MacLennan. James Lind. Born Edinburgh 1716. On HMS Salisbury in 1747 he allocated 12 men with scurvy. Cider. Seawater. Horseradish, mustard, garlic. Nutmeg. Elixir Vitriol . Oranges and Limes . Appraisal. “Frequency and Prevention of symptomless deep-vein thrombosis in long-haul flights: a randomised trial”. Group. . 8. Case Illustration. A Couple, Men . and women . , 55 yo want to travel with economy . Nick . Pavlakis. , MBBS, . MMed. (. Clin. Epi. ), . PhD. Royal North Shore Hospital. Sydney University. Outline. Aims of a Phase II study. Design aspects. Disease/population selection. Endpoint selection. Control trail . Define and classify (Types) randomized control trail, enumerate the steps in the conduct of Randomized Control . trail.. (. Jumanah. Muammar).. Randomized Control Trail. It is an epidemiologic experiment. It is the number 1 method of evaluation. . 18-70 years. Naïve . or failure to. PEG-IFN RBV. HCV RNA > 10 000 IU. /ml. No cirrhosis . No . HBV or HIV. coinfection. SURVEYOR-II study – Part 2: . glecaprevir. . pibrentasvir. in . genotypes 2 or 3 – Phase II . A-899-0059-12977. Presented by Professor Sarah Fidler . on behalf of the RIVER study team and investigators. Disclosures . MSD . donated drugs (. Raltegravir. and Vorinostat) and GSK contributed some of its intellectual property to the study through an industry academic partnership. Randomised trials face many challenges including slow or suboptimal recruitment;. Across trials, it is estimated that less than 50% meet their recruitment target or do so only with an extension to the original trial duration;. Part 2. Resident and Fellows Lecture Series. A. pril 12, 2016. Elizabeth Garrett-Mayer, . PhD. Hollings Cancer . Center. . Current State of Phase II. Lots of changes in the past several years. Phase I . open . label trial to determine the . cl. inical and . cost-. e. ffectiveness . of hypertonic saline (HTS 6%) and carbocisteine for . a. irway clea. r. ance versus usual care over 52 weeks in bronchiectasis (BE). 1. Queiroz LP, Peres MF, Piovesan EJ et al. . A nationwide population-based study of migraine in Brazil. . Cephalalgia. 2009;29(6):642-9.. 2. Queiroz LP, Silva Junior AA. . The prevalence and impact of headache in Brazi. Clinical trials . are required in the development of . new . medicines and improved treatments . for . patients. . The . information that clinical trials generate on the efficacy and safety of . treatments . 18 February 2020. -. A two-stage randomised phase II placebo controlled clinical trial. HIV pipeline for PrEP. Simon Collins. www.i-Base.info. UK-CAB: January 2020. Disclosure. -. A two-stage randomised phase II placebo controlled clinical trial. 2. Icahn School of Medicine at Mount Sinai, New York, United States, . 3. Hopital Tenon, Paris, France, . 4. Fundación Huesped, Buenos Aires, Argentina, . 5. AIDS Research Consortium . of Atlanta, Atlanta, United States, .