PPT-Phase II designs in Oncology

Nick Pavlakis MBBS MMed Clin Epi PhD Royal North Shore Hospital Sydney University Outline Aims of a Phase II study Design aspects Diseasepopulation selection Endpoint selection. Gary E. Foresman, MD. February 2012. “In 2010, about 600,000 Americans, and more than 7 million humans around the world, will die of cancer. . In the United States, 1 in 3 women and 1 in 2 men will develop cancer during their lifetime. . Arrow Attachment . Designs (2 PCBs). Arrow Attachment . Designs (1 PCB). Gary E. Foresman, MD. February 2012. “In 2010, about 600,000 Americans, and more than 7 million humans around the world, will die of cancer. . In the United States, 1 in 3 women and 1 in 2 men will develop cancer during their lifetime. . ASCO June 2014. Susan Dent. Medical Oncologist. The Ottawa Hospital Cancer Center. Ottawa, Canada. The problem . Cancer Survivors (Million) 2012 - 2018. Brigham, MGH. MSK. U Penn. Medstar. Washington. The Need for Measurement. Payers (Medicare and private insurers) are demanding quality, cost control, accountability, and predictability. Measuring . quality and value in cancer care now enabled by IT . Colorado School of Public Health. January 30. th. , 2013. Table of Contents. Orientation. Introduction. Components of a Phase I Trial. Phase I Trial Designs. Rule-Based Designs. Statistical Designs. References. Matthew Marston, . Pharm.D. ., BCPS. Miller Drug, LLC. Oral Oncolytics. Objectives. Identify . opportunities and challenges associated with the recent growth of the oral oncolytic market. .. Describe . Part 2. Resident and Fellows Lecture Series. A. pril 12, 2016. Elizabeth Garrett-Mayer, . PhD. Hollings Cancer . Center. . Current State of Phase II. Lots of changes in the past several years. Phase I . Medical Oncology Updates Presentation by Mary Hill Library Manager The Christie NHS Foundation Trust Putting it into context Cancer specialist hospital with strong research focus A lot of research fellows & one suggested they wanted the development research projects and educational the past at an the management malignant neoplasm requires a multi- disciplinary approach, which includes Gynecologic Oncology years. During subspecial What is clinical oncology?. “Intellectually . stimulating and rewarding. ”. “One of the most interesting and rapidly advancing areas of medicine”. “There’s no risk of getting . bored”. “People who have a real mission for what they do”. Debbie Bickes, MN, RN, OCN. ®. Supervisor, Oncology Patient Navigation. Northside Hospital Cancer Institute. Objectives. Explain oncology patient navigation. Provide a brief description of the history and evolution of oncology patient navigation. Shabbir. M.H. . Alibhai. , MD, MSc, FRCP(C). . Professor,. Dept. of Medicine, University Health Network and University of Toronto. Research Scientist, CCSRI. Learning objectives. To review cancer epidemiology in older adults. Dr Ollie Minton . National Picture. 29% . NHS spending is on patients in the . last year of their life. 1:3 . of the adult inpatient population is in the last year of their life. 1:10. is in their last admission.