PPT-The CLEAR Trial A 2x2 factorial randomised

open label trial to determine the cl inical and cost e ffectiveness of hypertonic saline HTS 6 and carbocisteine for a irway clea r ance versus usual care over 52 weeks in bronchiectasis BE. Asp irin and ticlopidine have been shown to be effective but both have potentially serious adverse effects Clopidogrel a new thienopyridine derivative similar to ticlopidine is an inhibitor of platelet aggregation induced by adenosine diphosphate Me to increase smoking cessation by maintaining NHS Stop Smoking Service attendance FAITH MATCHAM PHD STUDENT, DEPARTMENT OF PSYCHOLOGICAL MEDICINE, IOPPN Today ◦ BACKGROUND ◦ AIM % C. ontrolled Trials: a workshop. Ngaire. . Kerse. Professor and General Practitioner and asker of questions. . Key issues - . randomised. trials. There must be uncertainty. The question m. ust be answerable and feasible. Graeme MacLennan. James Lind. Born Edinburgh 1716. On HMS Salisbury in 1747 he allocated 12 men with scurvy. Cider. Seawater. Horseradish, mustard, garlic. Nutmeg. Elixir Vitriol . Oranges and Limes . Appraisal. “Frequency and Prevention of symptomless deep-vein thrombosis in long-haul flights: a randomised trial”. Group. . 8. Case Illustration. A Couple, Men . and women . , 55 yo want to travel with economy . placebo. REPORTING ADVERSE EVENTS AND COMPLETING THE REPORT FORM. Trial protocol code: ISRCTN30952488. Version 1, 17 November 2016. THIS PRESENTATION MUST BE USED WITH:. The Trial Protocol (. Section 2.9). Randomised trials face many challenges including slow or suboptimal recruitment;. Across trials, it is estimated that less than 50% meet their recruitment target or do so only with an extension to the original trial duration;. EMPA-REG Trial Randomised , double-blind, placebo-controlled cardiovascular outcomes trial The primary end point is the time from randomization to a composite outcome consisting of the first occurrence of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke (3 point Major Adverse Cardiovascular Events or 3-MACE) for asymptomatic severe carotid artery stenosis. . Alison Halliday. Nuffield Department of Population Health (NDPH). University of Oxford, UK . for the ACST-2 collaborators. ACST-2. is published online in . V4.1 25.06.2020. Issue. Clinical course / prognosis varies ++. between Crohn’s patients. Often greater impact on patients’ . lives than the . diagnosis. of CD itself. Jess et al IBD 2007. Solberg et al. . 1. Queiroz LP, Peres MF, Piovesan EJ et al. . A nationwide population-based study of migraine in Brazil. . Cephalalgia. 2009;29(6):642-9.. 2. Queiroz LP, Silva Junior AA. . The prevalence and impact of headache in Brazi. Non-randomised controlled trial. Randomised controlled trial . Parallel group. Cross-over. Single or double blind. Superiority or non-inferiority trial. 2. Trial design types. In a clinical trial design, there are a number of different types of comparisons that can be included:. testing an intervention . to. lower cardiovascular . disease risk for people with severe mental illnesses in primary . care. Alexandra Burton. Programme Manager. UCL Division of Psychiatry. Background . CONn. Syndrome screening and Evaluation in Primary care (CONSEP). Local presenter information. What is CONSEP?. CONSEP aims to increase screening and diagnosis of primary aldosteronism in people living with hypertension who attend general practice..