PPT-1 The Threshold for Platelets study: A prospective randomised trial to define the platelet

All Site Meeting 30 November 2022 IRAS ID 312405 NIHR CPMS ID 53274 REC Ref 22SC0186 ISRCTN Registry ISRCTN79371664 Funding NIHR HTA 131822 Sponsor University of Oxford Chief Investigator Prof Peter Watkinson . Joanna Rupa-Matysek. Hemostatic. System - . general. . information. Normal . hemostatic. system . vessel wall. circulating blood platelets. blood coagulation and . fibrynolysis. Bleeding. . Diathesis. 11q23 Family Conference. July, 2010. Paris-Trousseau Syndrome. Inherited disorder in which children may have:. Heart defects. Neurologic impairment. Growth delay. Low platelets. Due to deletion of the terminal . University. Faculty of Applied Medical Sciences. Department Of Medical Lab. Technology. 3. rd. Year – Level 5 – . AY 1434-1435 . 1. Hematology – 2, MLT 307. Bleeding disorders. . caused by . Graeme MacLennan. James Lind. Born Edinburgh 1716. On HMS Salisbury in 1747 he allocated 12 men with scurvy. Cider. Seawater. Horseradish, mustard, garlic. Nutmeg. Elixir Vitriol . Oranges and Limes . Thrombocytes. Platelets (Thrombocytes). 2- 4 micromillimeters in diameter. 250,000 – 400,000 per microliter . (too few thrombocytopenia – too many thrombocytosis). Lifespan on average 6 – 10 days. INFLAMMATION AND . IMMUNITY. Authors: Radu Andrei . Tomai. . . Cluj. . . . . Antoine . Joubert. . . Nantes. Supervisor. : Zsófia Mezei-Leprán, MD, . PhD. . : the smallest of the formed elements in blood, a disk-shaped, non-nucleated blood element with a fragile membrane, formed in the red bone marrow by fragmentation of . megakaryocytes. . Platelets tend to adhere to uneven or damaged surfaces, and there are an average of about 250,000 per mm.  . Platelets . are small colorless. ,. Non . nucleated and moderately refractive bodies which are considered to be the fragments of cytoplasm. .. . Diameter. : 2.5 μ (2 to 4 μ). Volume: 7.5 cu μ (7 to 8 cu μ. Physiologically; when platelets are activated, they undergo a sequence of reactions that are essential for hemostasis & important for the healing of damaged blood vessels. These reactions include:. Mohammad Faranoush,MD . Professor of pediatric Hematology Oncology. Iran University of Medical Sciences. Rasool Akram Medical Complex. Disclosures. No conflict of interest. Introduction. Platelets play a crucial role in hemostasis.. a a a T I P Idiopathic Thrombocytopenic Purpura Ishfaq. . Bukhari. Dec. 2012. In healthy vasculature, circulating platelets are maintained in an inactive state by nitric oxide (NO) and . prostacyclinre. (PGI2)leased by endothelial cells lining the blood vessels.. By . Dr. Sunita Mittal. Learning Objectives. Platelets Morphology. Hemostasis. Primary hemostasis. Platelet plug formation. Disorders of . p. rimary hemostasis. Secondary hemostasis. Disorders of secondary hemostasis. Platelets are the smallest formed elements in the blood, normally ranging in size from 2-4 microns. . Platelets function in the coagulation of blood.. A normal platelet count is 150,000-400,000/c.mm.in human .