PPT-Anti-platelet drugs Dr.

Ishfaq Bukhari Dec 2012 In healthy vasculature circulating platelets are maintained in an inactive state by nitric oxide NO and  prostacyclinre PGI2leased by endothelial cells lining the blood vessels. Abstract. Immune thrombocytopenic purpura (ITP), also known as idiopathic thrombocytopenic purpura is thought to be due to autoimmune disease. An abnormal autoantibody (immunoglobulin G) binds to the platelet membrane, causing removal by the spleen. If left untreated it could lead to bleeding and possibly death (. Morey A. Blinder, M.D.. Associate Professor of Medicine. and Pathology & Immunology. Objectives. Coagulation factor disorders and treatment. Disorders of platelets and platelet transfusion. Adjunctive drug therapy for bleeding. Dr. S. Parthasarathy . MD., DA., DNB, MD (. Acu. ), Dip. . Diab. . DCA, Dip. Software statistics, PhD(physiology). Mahatma Gandhi Medical College and Research Institute, . Puducherry. , India . Definition . Joanna Rupa-Matysek. Hemostatic. System - . general. . information. Normal . hemostatic. system . vessel wall. circulating blood platelets. blood coagulation and . fibrynolysis. Bleeding. . Diathesis. Platelet Counts. Vary with . Age (slight decrease in mean with increased age). Sex (Slightly lower mean in men). Consequences of Misdiagnosis of Inherited Thrombocytopenia. Wrong therapy. Wrong prognosis. Autoimmune (ITP). Childhood. Adult. Drug-induced. Heparin. Quinine, others. Immune complex (infection, etc). Alloimmune. Post-transfusion purpura. Neonatal purpura. ITP. Childhood ITP (most < 10 . Physiologically; when platelets are activated, they undergo a sequence of reactions that are essential for hemostasis & important for the healing of damaged blood vessels. These reactions include:. thrombocytopenia. ) constitutes an important cause of generalized bleeding.. A count less than 100,000 platelets/. μL. is generally considered to constitute thrombocytopenia. . Platelet counts in the range of 20,000 to 50,000 platelets/. Thrombotic . or thromboembolic disease is common and has severe consequences, including myocardial infarction, stroke, deep vein thrombosis and pulmonary embolism. Hemostasis. . is a finely regulated dynamic process of maintaining fluidity of the blood, repairing vascular injury, and limiting blood loss while avoiding vessel occlusion (thrombosis) and inadequate perfusion of vital organs.. At the end of this unit of study, the student should be able to:. Describe the normal morphology and number of platelets on a peripheral blood smear and state the normal life span and concentration of platelets in the blood.. . (. Drugs used in the treatment of fungal infections). Natural. . origin: Amphotericin B, . Nystatin, Griseofulvin, . . Natamycin (. Pimaricin. ), . Echinocandins. . Testing. . for. . Neurointerventional. . Procedures. Where. are . we. . now. ?. Josser . E. Delgado, M.D.. Yasha. . Kayan. , M.D.. Neuroscience Institute. Abbott Northwestern Hospital. Consulting Radiologists, Ltd. INTRODUCTION. Leprosy is a chronic infectious disease caused by . Mycobacterium . leprae. . . OR. Leprosy . is a chronic, communicable disease spread by prolonged, intimate contact with an infected person. Keerat. Chawla, SPT. Objectives. The audience will be able to understand about injuries and soft tissue structures in the body that respond well to PRP injections. The audience will learn about which patient populations would be appropriate for and may benefit from a PRP injection with continues PT after. .