PPT-Sorting by Cuts, Joins and Whole Chromosome Duplications

Ron Zeira and Ron Shamir Combinatorial Pattern Matching 2015 30615 G enome rearrangements Motivation I evolution Human genome project Motivation II cancer NCI 2001 Normal karyotype MCF7 breast cancer cellline. . waste. Sorting. line. Plastics. Yellow. . dustbin. Pet. . bottles. , . hollow. . wraps. , . foils. Ferry. , . sorting. , . pressing. No: linoleum . and. . floor. . coverings. , . wraps. . with. LPAR 2008 . –. Doha, Qatar. Nikolaj . Bjørner. , . Leonardo de Moura. Microsoft Research. Bruno . Dutertre. SRI International. Satisfiability Modulo Theories (SMT). Accelerating lemma learning using joins. Ron Zeira. and Ron Shamir. Combinatorial Pattern Matching 2015. 30.6.15. G. enome rearrangements. Motivation I: evolution. Human genome project. Motivation II: cancer. NCI, 2001. Normal karyotype. MCF-7 breast cancer cell-line. Bubble Sort . of an array. Inefficient --- . O ( N. 2. ). easy to code. , . hence unlikely to contain errors. Algorithm. for . outerloop. = 1 to N. for . innerloop. = 0 to N-2. if ( item[. Can use Access or Excel. Exact . duplicates: Same-same-same. Close duplicates: . Same-same-different. Prepared by:. Mark J. Nigrini. Copyright © 2012 by Mark J. Nigrini. All rights reserved.. introduction. Ariadna Pedraza Mensa. Genomics, 2017 . Master’s Degree in Advanced Genetics - UAB. Origin of new genes. DNA-based gene duplication (segmental duplications). Ohno’s model for duplications fate. RNA-based gene duplication (. 1. Sim. Joins on Product Descriptions. Surface s. imilarity . can be . high. for descriptions of . distinct. items:. AERO TGX-Series Work Table -42'' x 96'' Model 1TGX-4296 All tables shipped KD AEROSPEC- 1TGX Tables are . Lecture 18 SORTING in Hardware SSEG GPO2 Sorting Switches LED Buttons GPI2 Sorting - Required I nterface Sort Clock R eset n DataIn N DataOut N Done RAdd L WrInit S (0=initialization 1=computations) chromosome with a segment heavy line flanked by natural inverse-order repeats In principle inversionscan form by either intra- or interchromosomal exchanges The left side of the figure diagrams invers direct. or . inverted . and is indicated by the order of the bands with respect to the centromere in the karyotype designation. . The band closest to the centromere is written first in the short system; only the detailed system can pinpoint the exact location of the duplicated segment.. FLOW CYTOMETRY AppCATn nOTE minimal debris formation and large numbers of indiidual chromosomes for a well-resoled flow karyotype, protocols hae made use of stabilizing agents such as dialent c Prepared by Rania Naoufal, M.D.. Learning Objectives. Chromosome structure. Chromatin. Chromatin exists in several alternative configurations, depending on what that particular stretch of DNA is doing. Euploid. Have the . normal. chromosome number. Polyploid. A cell with . extra sets. of chromosomes. Ex: triploid (3n). Aneuploid. Cells missing a single chromosome or having an extra chromosome. Alterations in Chromosome Number. Genetic Drift is main force for changing allele frequencies. How do you define evolution?. Richard Goldschmidt 1940. hopeful monsters. Mutationism. . HGT/WGD!. Punctuated Equilibrium. Few genes / large effect.