PPT-Adapting for Success: The Genesis of Adaptive Designs

Andy Grieve SVP Clinical Trials Methodology Innovation Centre Aptiv Solutions 1 Outline Basic Principles of Adaptive Designs Why adaptive trials Differences Between Early Late Phase Adaptive Designs. Rebecca Orr, Ph.D. . Professor of Biology, Collin College. Background Information. Professor of Biology at Collin College in Plano, Texas. Two year public college, three campuses serving approximately 27,000 credit students. WHAT IS IT?. Preparing and modifying primary source documents so that all students can read and analyze them in their history classrooms.. Adapting Documents. RATIONALE. Often primary sources use complex or antiquated language. When is it appropriate to combine phasesVlad DragalinStatistical Research and Applications Global Biostatistics & Programming V. Dragalin | EMEA-EFPIA Workshop on Adaptive Designs | Dec 14, 2007 | Lon Acknowledgements to collaborators:. Steven . Julious. , Susan Todd, Jon Nicholl, and Jonathan . Boote. #ICTMC2015. Meandering journey towards routine trial adaptation: survey results on barriers to use of adaptive designs in confirmatory trials. Acknowledgements to collaborators:. Stevely. A, Todd S, . Julious. S, Nicholl J, Hind D, and Cooper C. . #ICTMC2015. 1. Investigation of the shortcomings of the CONSORT 2010 statement for the reporting of group sequential randomised controlled trials. Global Forum on Bioethics in Research. :. Emerging Epidemic Infections and Experimental Treatments. November 4, 2015. Lord Kelvin. I often say that when you can measure what you are speaking about and express it in numbers, you know something about it; but when you cannot measure it, when you cannot express it in numbers, your knowledge is of a meagre and unsatisfactory kind; it may be the beginning of knowledge, but you have scarcely in your thoughts advanced to the state of Science, whatever the matter may be.. Nick . Pavlakis. , MBBS, . MMed. (. Clin. Epi. ), . PhD. Royal North Shore Hospital. Sydney University. Outline. Aims of a Phase II study. Design aspects. Disease/population selection. Endpoint selection. Elizabeth Garrett-Mayer, PhD. Cody Chiuzan, MS. Hollings Cancer Center, MUSC. SRCOS June 2012. T cell attacking cancer cells*. * Azgad, The Cutting Edge, 2011. Dose Finding in Medical Research. In cancer research, usually small studies: 6 – 30 patients is the norm. Mahesh Parmar. MRC . Clinical Trials Unit at . UCL. Rationale . for adaptive trials. Our . adaptive trials and their setting. Discuss some broad practical and statistical challenges. Offer some solutions and thoughts. in . Teaching . and Learning. Southeast . Digital Learning Forum. UNC Charlotte, February 2019. Dale . P. Johnson. Director, Adaptive . Learning Initiatives. The future is already here – . it's just not evenly distributed.. Rigor in Grades K–5. Global Neutral . 01001a. . Global Warm Neutral. d3d1c8. . Global Accent On Dark. ffbf00. . Global Accent on Light. ff9800. . Global Accent Alt. 97c410. . ELA - Coral. ff5147. . D. esigns. 2. Steps in clinical . d. evelopment . p. rograms. Phase I:. . Studies on . dosing. Phase . III:. . Assess . therapeutic effect and benefit-risk in patients of candidate vs. standard of . What you should know about study design. Demonstrated on . Head of Statistics. nQuery. Lead Researcher. FDA Guest Speaker. Guest Lecturer. Webinar Host. HOSTED BY: . Ronan Fitzpatrick. AGENDA. Adaptive Designs in Confirmatory Trials. February 2019. Paola Davis. GDPR and events. Ensuring delegates give the right consents. Updating privacy policy. Promotion of events – updating mailing lists. Exhibition and sponsorships – how our partners behave with data.