PPT-Eukaryote Regulation and Gene Expression

Eukaryotic Gene Regulation How are genes turned on amp off in eukaryotes How do cells with the same genes differentiate to perform completely different specialized functions Evolution of gene regulation. Vibrio cholerae . HHMI 2011. Sara Fassio. Dr. Claudia H. ä. se. Dr. Yusuke Minato . Cholera. Infection of small intestine . Causes severe diarrhea and electrolyte loss. 3-5 million cases a year. 100,000- 120,000 deaths per year . What does the operon model attempt to explain?. the coordinated control of gene expression . in bacteria. bacterial resistance to antibiotics. how genes move between homologous regions of DNA. the mechanism of viral attachment to a host cell. Homeotic Genes. Type of master gene that controls formation of specific body parts during development. Antennapedia. . Expressed in the thorax causes legs to form. Expressed in the head causes legs to form there also. . Differential . expression, clustering, networks, and functional enrichment. STEMREM 201 Fall 2012. Aaron . Newman, Ph.D.. 10/17/12. A . genomics approach . to . biology involves…. A plethora of . Energy and nutrient cycles. Lindeman’s theory of . energetic ecologic . was . th. main trigger to initiate the international biological program (IBP) that run from 1964 to 1974 (European projects ended in the 80s). . University of Notre Dame. Kristin Hager, Associate Teaching Professor, Biological Sciences. Joseph O’Tousa, Professor, Biological Sciences. WH Freeman. Marc Mazzoni, Senior Editor, Life Sciences. Elaine Palucki, Editor, Adjunct Assistant Professor Biology, Brooklyn College. Biology Unit 04 Lesson 01. Prokaryotes – What are they?. Cells (usually single-celled) with no nucleus. Have no specialized organelles. Usually have: cell wall, cell membrane, ribosomes, genetic material, cytoplasm, and flagella or cilia. THINK ABOUT IT . How Does A Cell Know?. Which Gene To . Express. &. Which Gene Should Stay . Silent. ?. Prokaryotic Gene Regulation. @. To conserve resources, prokaryotes regulate their activities, producing only those genes necessary for the cell to function.@ . Chapter . 16. Genes and Development. Proteins can determine the DNA sequence by binding the major groove of DNA.. Proteins binding the minor groove cannot determine the exact sequence of bases.. Prokaryotic gene regulation. Anablep. . anablep. . with its “4 eyes”. Upper half of lids look aerially while the lower half looks into the water.. Cells of the two parts of the eye exhibit differential gene expression. Individual bacteria respond to environmental change by regulating their gene expression. © 2017 W. H. Freeman and Company. CHAPTER 28 . Regulation of Gene Expression. DNA elements that control transcription. Protein factors that control transcription. Lac. operon as a model for regulation. RNA can destabilize mRNA. Single-stranded RNA can affect gene expression. Double-stranded RNA can affect gene expression. All of above. . Before their study, it is known that. Single stranded RNA can cause RNA interference. Controlling gene expression is often accomplished by controlling transcription initiation.. Regulatory proteins . bind to DNA to either block or stimulate transcription, depending on how they interact with RNA polymerase.. AP Bio – Ch. 16-21. Unit 6 – Overview. Ch. 16 – The Molecular Basis of Inheritance (DNA). Ch. 17 – Gene Expression: From Gene to Protein. Ch. 18 – Regulation of Gene Expression. Ch. . 19 . – .