PDF-Secondary structure of RNAAs introduced in Chapter 2, RNA is a chain-l

The versatility of RNA 55 G 2 2A 2OOOOCOH O. Why do we want to know protein structure?. Classification. Functional Prediction. What is protein structure?. Primary - chains of amino acids. Secondary - interaction between groups of amino acids. Tertiary - the organization in three dimensions of all the atoms in a polypeptide. E – Recall the different structures of proteins and the test for proteins..  . C. . – Describe how a peptide bond is formed. . Describe the different structure of proteins.  . A – . Explain how the structures of a polypeptide build up and how changes to this may affect function. Yann. . Ponty. (VARNA), CNRS/. Ecole. . Polytechnique. , France. Jim Procter . (. JalView. ), University of Dundee, UK. Goals. To help your . survive. . the . RNA data jungle. .. To conceptually and . loops (coil). Bovine . carboxypeptidase. A. Figure 6-28. Tertiary . structures . may contain . common patterns, or motifs, of secondary structures (= . supersecondary. structures) . βαβ. β. -hairpins. . (64 cells). Tube-like structure. (64 cells). Flattened structure. (64 cells). Surface area . . 420,000 . . m. 2. (168 cell surfaces . . 2500 . . m. 2. /cell. surface). Surface area/volume . loops (coil). Bovine . carboxypeptidase. A. Figure 6-28. Tertiary . structures . may contain . common patterns, or motifs, of secondary structures (= . supersecondary. structures) . βαβ. β. -hairpins. Introducing proteins. Proteins. are a diverse group of large and complex polymer molecules, made up of long chains of . amino acids. .. They have a wide range of biological roles, including:. structural:. . Miguel . Andrade. Faculty of Biology, . Johannes Gutenberg University . Institute of Molecular Biology. Mainz, Germany. a. ndrade@uni-mainz.de. Secondary structure prediction. Amino acid sequence -> Secondary structure. strech. of the polypeptide chain. 5.4 Å rise,. 3.6 . aa. /turn.  1.5 . Å/. aa. N-term. C-term. prototypical .  = -57. ψ. . = -47. α-Helices have a dipole moment, due to . unbonded. and aligned N-H and C=O groups. BMI/CS 776 . www.biostat.wisc.edu/bmi776/. Spring . 2018. Anthony Gitter. gitter@biostat.wisc.edu. These slides, excluding third-party material, are licensed . under . CC BY-NC 4.0. by Mark . Craven, Colin Dewey, and Anthony Gitter. Dr. Ahmed Mujamammi. Dr. . Sumbul. . Fatma. Learning outcomes. What are proteins?. Structure of proteins:. Primary structure.. Secondary structure.. Tertiary structure.. Quaternary structure.. Denaturation of proteins.. Proteins are biopolymers, made of the 20 L- . α. -amino acids linked by peptide bonds.. Polypeptide backbone is a repeating sequence of. . N-C-C-N-C-C…. The side chain or R group is not a part of the backbone or the peptide bond.. Some of the slides are adapted from Dr. Dong Xu’s lecture notes. Why secondary structure prediction?. Accurate secondary structure prediction can be an important information for the tertiary structure prediction. , . Brent O. . Cezairliyan. , Robert A. Grant, Jesse C. . Cochrane, . and Robert T. . Sauer - . Department . of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 . Presented by . Gayathri Priya Ravichandran.