PPT-CELL INJURY NECROSIS Dr.V.Shanthi

Associate Professor Department of Pathology Sri Venkateswara Institute of medical sciences Tirupathi CELL INJURY Cellular responses to stress amp injurious stimuli Normal cell homeostasis. Grace Denton & Stephanie . Tristram. G.E.Denton@warwick.ac.uk. S.C.Tristram@warwick.ac.uk. What are some of the causes of cell injury and cell death?. Causes of cell injury .  . CHIPING: C. . (Adaptations, injury and death). (. 2 of 5). Ali Al Khader, M.D.. Faculty of Medicine. Al-Balqa’ Applied University. Most injurious stimuli are grouped into:. Oxygen deprivation. Chemical agents. Unite one. Second Lab. .. The two lung abscesses seen here are examples of . liquefactive necrosis. in which there is a liquid center in an area of tissue injury. One abscess appears in the . upper lobe . J. Matthew Velkey. matt.velkey@duke.edu. 454A Davison, Duke South (green zone). Cellular Adaptation to Injury or Stress. Injury or Stress. Increased demand. Decreased stimulation or lack of nutrients. . ADAPTATION . TO ENVIRONMENTAL STRESS. Lab:2&3. Proliferative endometrium . A. . A section of the uterus from a woman of reproductive. . age reveals a thick endometrium composed of proliferative glands in an abundant . Assist.Prof.Dr. . . Baydaa. . H.Abdullah. Reversible . cell injury . . It . is called also . degeneration . .It is accumulation of normal substances (glycogen ,water) or abnormal (. Amyloid. ) inside the cell due to injury agent. classified into two main groups . of membrane integrity and leakage of cellular content ,largely resulting from the degradative action of enzymes on lethally injured cells. The enzymes responsible for digestion of the cell may be derived from the lysosome of dying cells themselves and from lysosomes of leukocytes cells. Etab. A. AL-. Mosawe. Cell death. Cell . death falls into two main categories: . Apoptosis . and . necrotic cell death.  . Types of Cellular Necrosis. Liquefaction necrosis Digestive enzymes released by necrotic cells soften and liquefy dead tissue. Occurs in tissues, such as the brain, that are rich in hydrolytic enzymes.. Stage . 3. Collage of Pharmacy / . AL . Mustansiriyah. University. . . Lab . 2. . Cell Injury. If the cells fail to adapt under stress, they undergo certain changes called . Cellular injury. Cellular injury . can occur in a number of different ways. The extent of injury that cells experience is often related to the intensity and duration of exposure to the injurious event or substance. Cellular injury may be a reversible process, in which case the cells can recover their normal function, or it may be irreversible and lead to cell death. . Necrosis is defined as a . localised area of death of tissue followed later by degradation of tissue by hydrolytic enzymes librated from dead cells . It is invariably accompanied by . Inflammatory reaction . . Cellular. . Responses. . to. Stress and . Noxious. . Stimuli. Sequence. . of. . reversible. . cell. . injury. and . cell. . death. . . Necrosis. and . apoptosis. are the . two. major . 1- Necrosis. 2- Apoptosis. 3-Gangreen. 4-Pathological calcification . 1. Necrosis . is . irreversible cell . death . characterized by loss of membrane . integrity and leakage of cellular contents . culminating in . Pathology lec2. H. omeostasis. Normal cell is in a state of functional and structural balance with neighboring cells. With a narrow range to handle its physiologic demand and maintaining a steady state..