PPT-AthEROSCLEROSIS Dr.V.Shanthi

Professor and HOD Department of Pathology OVERVEIW DEFINITION OF ATHEROSCLEROSIS RISK FACTORS HYPOTHESIS REGARDING PATHOGENESIS COMPLICATIONS CLINICAL MANIFESTATIONS ATHEROSCLEROSIS Atherosclerosis means . “Plaque Man” – QGEM 2009. Atherosclerosis: An Introduction to the Disease. Project Design: A Synthetic Biology Approach to Targeted Drug Delivery. Binding. Inducibility. Effectors. Results: What did we accomplish?. Dr. Gehan Mohamed Dr. Abdelaty . S. hawky. Learning objectives.  . Definition . of arteriosclerosis and mention the three patterns of it?. Mention definition, risk factors, gross morphology, and common sites of atherosclerosis?. Soft Tissue Calcification. Arterial: Arteriosclerosis or atherosclerosis, diabetes. Parasitic: Cysticercosis, Trichinosis. Collagenoses: Scleroderma, dermatomyositis. Metabolic: Hyperparathyroidism, gout. Society for Heart Attack Prevention and Eradication (SHAPE). Houston, TX. Noninvasive Screening . of . Asymptomatic Atherosclerosis for Primary Prevention of CVD. The Problem. > . 15 . Million Heart Attacks Each Year. Atherosclerosis. Atherosclerosis is . a disease in which . plaque builds . up inside your arteries. Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your . body. Plaque . Terms. Arteriosclerosis – hardening of the arteries. Atherosclerosis – a form of arteriosclerosis. Venosclerosis. Arteriolosclerosis . Step One of Atherosclerosis. Endothelium injured. The tunica interna is injured in some way by bloodborne chemicals, hypertension, components of cigarette smoke or viral or bacterial infections. Almost any type of chronic infection – including periodontal disease can cause the damage.. Overview. Buildup of plaque in arteries. Causes hardening of the arteries. Restricts blood flow. Atherosclerosis in the heart is called . Coronary Artery Disease. Sudden plaque rupture or clotting can cause the heart muscle to die.. Why is Atherosclerosis known as a heart disease?. Atherosclerosis is when there is a buildup of plaque on artery walls. This creates a smaller passageway for blood to go through, increasing blood pressure. Overview: Why is it Called “Heart Disease”. Atherosclerosis is a type of arteriosclerosis (the hardening of the arteries.) . A thrombus (blood clot) can form because of the buildup of plaque.. Diseases that can develop from atherosclerosis : angina (chest pain), carotid artery disease, coronary artery disease, and kidney disease.. Arterio. sclerosis. Thickening/Hardening of Arteries. Predominantly . Athero. sclerosis. Normal vessel structure. Pathophysiology of Brain & Body . USSJJQ-20-3. Normal Structure. Normal Structure. NORMAL ARTERIAL WALL. PROCESS OF ATHEROSCLEROSIS. RISK FACTORS OF ATHEROSCLEROSIS. COMPLICATIONS OF ATHEROSCLEROSIS. DEFINITION. Atherosclerosis. is defined as a progressive disease characterized by the accumulation of lipids and fibrous elements in the large arteries.. The exact mechanisms underlying these diseases are still not fully understood, but increasing evidence suggests that diet-induced monocytes and macrophage dysfunction plays a major causal role in the conversion of acute into chronic inflammation and . Pathophysiology. Atherosclerosis is a chronic inflammatory disease. . Atherosclerosis . begins with fatty streak which is an accumulation of lipid laden foam cells in the intimal layer of the artery. . A cross-sectional study. 595 gout patients. T. ophi-free group (76.47%) and the tophi group (23.53%). Gout patients. Interaction with IR. Hepatic IR. (. HOMA index. ) . Peripheral IR. (. Gutt index.