Maheshwari A Fischer M Gambetti P Parker A Ram A Soto C et al Recent US Case of Variant CreutzfeldtJakob DiseaseGlobal Implications Emerg Infect Dis 2015215750759 httpsdoiorg103201eid2105142017 ID: 1045191
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1. Figure 3Figure 3. Results of histopathologic and immunohistochemical analyses for a US patient with variant Creutzfeldt-Jakob disease. A) Hematoxylin and eosin staining shows many typical florid plaques (A, arrow) occasionally forming clusters; large vacuole spongiform change is also present (original magnification ×10). B) Plaques often not of the florid type along with spongiform change are present in cerebellum (arrows; original magnification ×20). C, D) Prion protein immunostaining confirms the presence of PrP in the plaques, which intensely immunostained (C; original magnification ×10), and highlights small round cells surrounded by short processes (D, antibody 3F4; original magnification ×40). E) Under high magnification, a prion plaque with spongiform change is seen in the left frontal cortex (original magnification ×400).Maheshwari A, Fischer M, Gambetti P, Parker A, Ram A, Soto C, et al. Recent US Case of Variant Creutzfeldt-Jakob Disease—Global Implications. Emerg Infect Dis. 2015;21(5):750-759. https://doi.org/10.3201/eid2105.142017