PPT-Sequence and Structure Analysis of Surface Glycoprotein of SARS-CoV-2 from India Variants

COVID19 is a pandemic across the world It is caused by a novel coronavirus severe acute respiratory syndrome coronavirus 2 SARSCoV2 The SurfaceSpike Glycoprotein of SARSCoV2 which plays a key role in the receptor recognition and cell membrane fusion process is composed of two subunits S1 and S2 In the present work we have searched for SurfaceSpike glycoprotein in the NCBI protein database and origin from India the search hit out 192 protein sequences as on 20 June 2020 Further the sequences were aligned using SurfaceSpike glycoprotein from WuhanChina Origin and on the basis of the sequence length of 1273 the sequences were screened Out of 192 input protein sequences 177 sequences were complete in the length of 1273 aminoacids Comparing all the sequences via sequence alignment mode in MEGAX exhibited a complex diversified outcome and reported 32 sequences The protein sequence id QKI286851 was identified as a root and 31 protein sequences as a mutantvariant QKI286851 was subjected to 3D protein structure modelling As no fulllength structural template was identified in the database Automated homology modelling SwissModel server and threading based ITasser were considered for the structure determination SwissModel reported a partial structure from amino acid length 27 to 1146 A fulllength structure is obtained from the ITasser server The structures were analyzed using the ProSA and Ramachandran plot 31 identified mutations were manually incorporated in the protein structure and a total of 31 mutants were created Further these proteins are in a process to study and understand the structural changes and their impact on the proteinprotein interaction and proteindrug interaction. One Health Partners Monthly COVID-19 WebinarCoordinated by the CDCOne Health Office in partnership with the One Health Federal Interagency COVID-19 Coordination OH-FICC GroupOne Emergx000Bg x000Crx000Ex000Fes Ix000Bfetx000Ex000BsISSN Prx000Btx001A x001Bx001Bx001Bx001B-x001Cx001Dx001Ex001C x000Blx000Bex001A Jx000Eurx000Bal hx000Emepage https//wwwtax000Bdfx000Ex000Blx000Bex000 SARS-CoV-Updated 3/2/2020Samuel R Dominguez MD PhD and Ann-Christine Nyquist MD MSPH1What is the SARS-CoV-2and where did it come fromSARS-CoV-2 previously called 2019 novel coronavirusis a coronavirus The more the virus circulates, the more the virus will evolve
Most changes have little to no impact on the virus’s properties or behaviour
However, some changes to SARS-CoV-2 lead to the emergence of variants that may affect: An Initiative of DBT-AIs. Coordinated by . National Institute of Biomedical Genomics (NIBMG), . Kalyani. . P. articipating Institutes:. Teams:. . . NIBMG:. . Arindam. . Maitra. , . Nidhan. Biswas, . David J. Weber, MD, MPH, FIDSA, FSHEA, FRSM (London). Sanders Distinguished Professor of Medicine, Pediatrics and Epidemiology. Associate Chief Medical Officer. Medical Director, Hospital Epidemiology. 1,2,3. *. , . Sarah Temmam. 4. *,. . Christèle. Huon. 4. , Sylvie Behillil. 5,6. , Vincent Gajdos. 7,8, . Thomas Bigo. t4,9. , Thibaut Lurier. 10,11,12. , Delphine Chrétien. 4. , . Marija. Backovic. k. . |. science thinking resources and pedagogy . Bioinformatics in the classroom. Exploring the genome of SARS-CoV-2 using bioinformatics . As you work through this PowerPoint there is information, . A drug repurposing approach for COVID-19. Md. Riad Chowdhury. 1. , . Md. . Adnan. 2,*. , . Md. Nazim Uddin . Chy. 1,*. , . A.T.M. Mostafa Kamal. 1. 1. Department of Pharmacy, International Islamic University Chittagong, . eucaryotic glycoprotein tein has layer of of X- ray diffraction diffraction However, chemical analysis of the halobacterial surface layer as well as comparison with surface layers of other archaebacte Virupaksha. A. Bastikar. 1. ; . Pramodkumar. Gupta. 2. ; Alpana V. Bastikar. 3. and Santosh S. Chhajed. 4. 1. Amity Institute of Biotechnology, Amity University, Mumbai, Maharashtra;. 2. School of Biotechnology and Bioinformatics, D. Y. . Eckerle I, Kapaun A, Junghanss T, Schnitzler P, Park S, Jänisch T. Dengue Virus Serotype 3 Infection in Traveler Returning from West Africa to Germany. Emerg Infect Dis. 2015;21(1):175-177. https://doi.org/10.3201/eid2101.141145. Kratzel A, Todt D, V’kovski P, Steiner S, Gultom M, Thao T, et al. Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols. Emerg Infect Dis. 2020;26(7):1592-1595. https://doi.org/10.3201/eid2607.200915. (virus). Guam Department of Public Health and Social Services. Disclaimer: This is a rapidly evolving situation. Information and guidance are constantly changing. Information presented in these slides may already be out-of-date..