PPT-Targeting SARS-COV2 Main Protease Using HTVS and Simulation Analysis: A Drug Repurposing

Virupaksha A Bastikar 1 Pramodkumar Gupta 2 Alpana V Bastikar 3 and Santosh S Chhajed 4 1 Amity Institute of Biotechnology Amity University Mumbai Maharashtra 2 School of Biotechnology and Bioinformatics D Y . By. . SOMESHWAR.K. M.PHARM.. II - SEMESTER . . . Department of Pharmaceutics. University College of Pharmaceutical Sciences,. KAKATIYA UNIVERSITY. Stereochemistry. Many biomolecules, including proteins, carbohydrates and DNA, are chiral. . A typical drug molecule acts by docking with a target biomolecule such as an enzyme or receptor. These drugs are often chiral, and the two enantiomers may differ greatly in efficacy.. Stereochemistry. Many biomolecules, including proteins, carbohydrates and DNA, are chiral. . A typical drug molecule acts by docking with a target biomolecule such as an enzyme or receptor. These drugs are often chiral, and the two enantiomers may differ greatly in efficacy.. Robert D. Blagg. Todd M. Franke. NHSTES – May 28, 2014. 2. Simulation training in public child welfare: An approach to evaluation . Outline. Background & . Context. The Simulation Process. Evaluating . Peptidase . IV (DPP4) . Inhibitors . as . Potential Agents . to treat SARS-CoV-2 (2019-nCov) . Infection. DPP4 activity is increased in patients with type-2 diabetes and the increased risk of type-2 diabetic patients to SARS-CoV-2 infection, which suggests that DPP4 class of drugs have the potential to be used as novel therapy. Our molecular modeling studies suggest that. Dejan Milenković. . 1,. *, . Dušan Dimić. . 2. , . Edina . Avdović. 1. , . Jelena . Đorović. . Jovanovi. ć. . 1. , . Žiko . Milanović. . 3. , . Marko . Antonijević. 1. , . Jasmina . Dimitrić-Marković. A drug repurposing approach for COVID-19. Md. Riad Chowdhury. 1. , . Md. . Adnan. 2,*. , . Md. Nazim Uddin . Chy. 1,*. , . A.T.M. Mostafa Kamal. 1. 1. Department of Pharmacy, International Islamic University Chittagong, . Mikki Jaramillo, Indiana University School of Dentistry . Mythily. Srinivasan, BDS, MDS, PhD, Indiana University School of Dentistry. Thankam. . Thyvalikakath. , DMD, BDS, MDS, PhD, Indiana University School of Dentistry. Kai Guo. 1. *, . Zhihan Wang. 1,2. *, Pan Gao. 1. *, . Qinqin. Pu. 1. , . Min Wu. 1$. , Changlong Li. 2$. , and . Junguk. Hur. 1$. 1. Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202, USA. Iyshwary Vigneswaran Warren. 1,2,3. , Christopher Kupitz. 3. , Soichi Wakatsuki. 2,3. Departments of Bioengineering. 1. & Structural Biology. 2. , SLAC National Accelerator Laboratory. 3. . Introduction. Aaron D. Schroeder, Ph.D.. Senior Data Research Scientist. Social & Decision Analytics Lab. Biocomplexity Institute of Virginia Tech. Every Repurposing Is a New “Investigation”. Locating the Data Repurposing Discussion. Department Medicine. UF College of Medicine. Randomized trial of bicalutamide to block . TMPRSS2 in males with COVID-19 infection. UF-CTSI Pilot grant project. Association between . Cancer and COVID-19 Biology. Also Called . 3CL Proteinase. Collaborative Curriculum Development Program 2020. What does SARS-CoV-2 look like? . Severe acute Respiratory Syndrome -Coronavirus-2. Large (~30Kb) . +RNA genome. . https://viralzone.expasy.org/764?outline=all_by_species. . Treatment. . of . Cardiovascular. . Disease. . Caused. . by . SARS-. CoV-. 2. Joseph. . Loscalzo,. . MD,. . PhD. Brigham. . and. . Women’s. . Hospital. . |. . Harvard. . Medical. .