PPT-Chapter 12 Antimicrobial Agent Mechanisms of Action and Resistance

Copyright 2015 by Saunders an imprint of Elsevier Inc Introduction Antimicrobial agents Chemical compounds to kill or suppress microorganisms Antibiotics Natural semisynthetic or synthetic molecules used to treat or prevent disease . % . survivors. Penicillin. Untreated. Days. Penicillin increased the chance of survival from 10% to 90%. Patients with. pneumonia . and bacteria . in the blood. Adapted from Austrian . et al.. Ann. Int. Med 1964; . N. gonorrhoeae. . A Review. INTRODUCTION. Progressive antimicrobial resistance in . Neisseria gonorrhoeae . is an emerging public health threat. The Public Health Agency of Canada (the Agency) released updated recommendations in July 2013 for the diagnosis, treatment, follow-up and reporting of gonorrhea. % . survivors. Penicillin. Untreated. Days. Penicillin increased the chance of survival from 10% to 90%. Patients with. pneumonia . and bacteria . in the blood. Adapted from Austrian . et al.. Ann. Int. Med 1964; . What are antibiotics?. Definition: chemicals produced by one microorganism to kill or inhibit the growth of other microorganisms. Now included the semi-synthetic antibiotics. Effective against bacteria. . Dr Andrea Ammon, ECDC Director, . 27 June 2017, European Parliament. 0. 200. 400. 600. 800. 1000. 1900. 1920. 1940. 1960. 1980. 2000. 1918. Influenza pandemic. 1924. Plague: last human-to-human transmission. Global . Overview: Evolving challenge. Nordic Health Summit. Oslo . 10 May 2016. Keiji . Fukuda . Where are we. ?. Why?. Where do we want to . go?. How?. I. n 20. th. Century, deaths from infections dropped (United States pattern). % . survivors. Penicillin. Untreated. Days. Penicillin increased the chance of survival from 10% to 90%. Patients with. pneumonia . and bacteria . in the blood. Adapted from Austrian . et al.. Ann. Int. Med 1964; . Komal. . Pareek. 1. Key Terms. Antibiotic = A drug that kills or inhibits the growth of microorganisms. Resistant = Somewhat arbitrary designation that implies that an antimicrobial will not inhibit bacterial growth at clinically achievable concentrations. Third Lecture . 2022. Assist. Prof. Mohammed AboKsour. It is the ability of microbes to grow and multiply in the presence of antimicrobial agent that would normally kill them or limit their growth. The concentration of drug at the site of infection must inhibit the organism and . Consequences of AMR. What can we do ?. Microbiology and the antibiotic apocalypse. Dr Dave Whitworth. dew@aber.ac.uk. Reader in Biochemistry. Microbiology and the antibiotic apocalypse. What are antibiotics ?. SECURING THE FUTURE FROM DRUG-RESISTANT INFECTIONS REPORT TO THE SECRETARY-GENERAL OF THE UNITED NATIONS APRIL 2019 TABLE OF CONTENTS Key messages in this report .................................. Resistance : T ackling a crisis for the health and wealth of nations The Review on Antimicrobial Resistance Chaired by Jim O’Neill December 2014 Contents What is antimicrobial resistance? RESISTANCE Interagency Task Force on Antimicrobial Resistance Co - Chairs: Centers for Disease Control and Prevention Food and Drug Administration National Institutes of Health Participating Agencie s 1. 1. Antibacterial resistance in ophthalmic infections: a multi-centre analysis across UK care settings//BMC Infectious Diseases.- volume 19, Article number: 768 (2019) . Educational MODULE. November 2020.