A systematic literature review found high rates of comorbidity between migraine and bipolar disorder 1 Mean prevalence of bipolar disorder among people with migraine 5990 Mean prevalence of migraine among people with bipolar disorder 304 ID: 1007177
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1. MigraineBipolar disorderA systematic literature review found high rates of comorbidity between migraine and bipolar disorder:1Mean prevalence of bipolar disorder among people with migraine: 5.9–9.0%Mean prevalence of migraine among people with bipolar disorder: 30.4%A study that screened for bipolar disorder among people with migraine found that:2 Bipolar disorder was comorbid in 19.2% of people with migraineThe presence of bipolar disorder comorbidity was associated with significantly higher MIDAS scores (37.0 versus 19.0, p<0.05)The comorbidity of migraine and bipolar disorder complicates treatment – some antidepressants that are prescribed for migraine prevention may unfavourably alter the disease course of bipolar disorder1CI=confidence interval; MIDAS=Migraine Disability Assessment; OR=odds ratio1. Leo & Singh. Scand J Pain 2016;11:136–145;2. Kivilcim et al. Neuropsychiatr Dis Treat 2017;13:631–641Risk of bipolar disorder in people with migraine compared with control individuals1StudyOR (95% CI)Breslau et al., 1991Merikangas et al., 1990Saunders et al., 2008Increased risk for people with migraineDecreased risk for people with migraine