PPT-RED CELL MEMBRANE DISORDERS

Dr Ali Khazaal Jumaa FIBMS Int Medicine FIBMS Hematology The red cell membrane RBC membrane plays a critical role in the maintenance of the biconcave shape and integrity of the red cell. Healthy red blood cells are round and they move through small blood vessels carrying oxygen to all parts of the body In SCD the red blood cells become hard and sticky and look like a Cshaped farm tool called a sickle Sickle cells die early which cau Also its possible for otherwise healthy people to develop severe illness so any one concerned about their illness should consult their doctor There are emergency warning signs that should signal anyone to seek medical care urgently Emergency Warning . By Dr. . Vani. Gupta. 2. “Polarity” . of the . membrane. Na. +. K. +. Mg. 2+. Ca. 2+. H. +. HCO. 3. -. Cl. -. SO. 4. 2-. PO. 3. -. protein. inside. (in mM). 14. 140. 0.5. 10. -4. (pH 7.2). 10. Learning Objectives. outline the roles of membranes within cells and at the surface of cells. state that plasma (cell surface) membranes are partially permeable barriers. describe, with the aid of diagrams, the fluid mosaic model of membrane structure. بسم الله الرحمن الرحيم. Objectives. Define Membrane . Potential. ?. Describe the electrical potential across the cell membrane.. Explain the Resting . Membrane and its cause . (Concentration . “Head” regions of phospholipids are hydrophilic, so love water. “Tail” regions are hydrophobic, so fear water and “hide” from it. In other words, cells membranes form in water because they HAVE to!. . “ Life is a . dynamic equilibrium of hundreds and thousands and millions of chemical and biochemical reactions going on between non-living substances at ionic and molecular level”.. . -. Panday. Learning . Goal . Describe . the composition and function of the lipid bilayer in cell membranes.. Cell Membranes. Cell membranes. . are semipermeable so that nutrients can enter the cell and waste products can leave.. All text comes from:. Membrane Function Part 1, . by W.R. Healy, K.N. Prestwich, and J. . Rymer. . © 2010. What is a model?. Models are . conceptual representations used to explain and predict phenomena. . Structure. Main component is phospholipids that are arranged in a double layer (. bilayer. ). Has scattered proteins within the phospholipids. Regulate what enters/leaves cell. Function . Nucleus. Structure. What is the plasma membrane?. A flexible boundary between the cell and its environment which maintains . HOMEOSTASIS. within the cell. **Remember that . HOMEOSTASIS. is a state of balance/equilibrium within the cell.. primarily . of ______.. DNA. Protein. Carbohydrates. Phospholipids. 2. The . phospholipids in the cell membrane are arranged in a bilayer (double layer). How are the phospholipid molecules arranged in this bilayer?. Lec3/cytology . 2021-2022. By: . MSc. . Farah E. . Ismaeel. Objectives of this lecture. Learn about . . cell . membrane . permeability. . . Learn . about . the ways of molecules transport via cell membrane. . Introduction . Red blood cells are characterized by a biconcave shape aids efficient navigation through narrow vessels.. Surface antigens on red blood cells determine individual blood types.. Lack of nucleus and organelles enables high hemoglobin concentration for oxygen transport..