PPT-Autoimmunity and imunopathology

Tomas Milota MD Department of Immunology Department of Rheumatology Second Medical Faculty Charles University and Motol University Hospital Prague Basic characteristics. Self-tolerance: concept, significance. Mechanisms of central and peripheral tolerance: deletion, anergy, regulatory T cells . Pathogenesis of autoimmunity: roles of susceptibility genes and environmental factors . Auto. i. mmune . Disease Ontology. Alexander D. Diehl. 6/13/12. Neurological Disease Ontology (ND). Based on the Ontology for General Medical Sciences. Incorporates parts of NIF-Dysfunction. Three initial . Department of Rheumatology. University of Stellenbosch. Immunology. Innate and adaptive immunity: cells. Innate and adaptive immunity. MHC class I and II. Complement system. Activation of innate immunity. Special thanks to Dr. Todd Watts DC . Barbara Stuart, APRN, NP-C, CEN. Integrative Medical Practitioners. Presented by . DoTERRA. Diamond Melody . Covino. Recommended Reading. Hormonal cycle of Thyroid. Mark S. Anderson, MD, PhD. UCSF. Disclosures. Research support from Juno Therapeutics. Consultant for . Sanofi. 2. 3. Lecture outline. Principles of immune regulation . Self-tolerance; mechanisms of central and peripheral . 1,2. Norbert Gleicher, MD. 1,3. 1. Center for Human Reproduction and Foundation for Reproductive Medicine; . 2. Department of Obstetrics, Gynecology and Women’s Health, Albert Einstein College of Medicine; . 8/17/2012. LONG TERM PRE-DM WITH MULTIPLE AUTOANTIBODIES. 36336-0 DAISY Study. Diabetes Onset. LEVEL Autoantibodies. DIPP Populations Study: Quartile Levels Insulin Autoantibodies (6 month post first IAA) and progression to Diabetes . Anna Postolova, MD MPH. Allergy/Immunology/Rheumatology. Menlo Medical Clinic. Stanford Health Care . Disclosures . Nothing to disclose. Objectives. Recognize aspects of history and presentation that are suggestive of a primary immunodeficiency or immune dysregulatory syndrome in rheumatology patients. AUTOIMMUNE DISEASES. AUTOIMMUNITY. The . term autoimmunity refers to a failure of the body’s immune system to recognize its own cells and tissues as “self”, Instead immune responses are launched against these cells and tissues as if they were foreign or invading bodies. By: . Dr Puneet Kumar Gupta . Assistant Professor, Microbiology. 1. 2. 3. 4. 5. 6. 7. 8. Tolerance and Autoimmunity. 9. What is tolerance?. Mechanisms to protect from potentially self reacting lymphocytes. . immunopathology. concerns disorders caused by alterations of the immune response. 3 main categories of alterations:. . excessive response hypersensitivity reactions. inappropriate . . response . . immunological tolerance. Immunological . tolerance is a state of unresponsiveness to a particular antigen to which a person has been exposed earlier. .. . . The important aspect of tolerance is the self-tolerance, which prevents the body to mount immune response against self-antigens. AND AUTOIMMUNE DISEASES RAKESH SHARDA Department of Veterinary Microbiology NDVSU College of Veterinary Science & A.H., MHOW Spleen Lymph Nodes Thymus Bone Marrow T cell Development  In normal i LECTURE : 07 LEARNING OBJECTIVES : The student should be able to: Describe the term "autoimmune", indicate if it is either Define the term "autoantibodies". Determine if the autoantibodies eit