PPT-Autoimmunity and Tolerance

Chris Lancaster Emily Mathews Jake Turner Questions cjlancasterwarwickacuk JakeTurnerwarwickacuk EKMathewswarwickacuk Definitions Immunological Tolerance Unresponsiveness . Datum and Tolerance Accumulation . Possible Tolerance Conditions . Block Example . Specific Tolerances for Slip and Press Fits. Machine Tolerances . Tolerance Block . This presentation includes the following concepts . Self-tolerance: concept, significance. Mechanisms of central and peripheral tolerance: deletion, anergy, regulatory T cells . Pathogenesis of autoimmunity: roles of susceptibility genes and environmental factors . Quiz. Emily Matthews (. e.k.matthews@warwick.ac.uk. ). Chris Lancaster (. c.j.lancaster@warwick.ac.uk. ). Jake Turner (. jake.turner@warwick.ac.uk. ) . Question 1. Define autoimmunity ( 4 marks). 1) . Mark S. Anderson, MD, PhD. UCSF. Disclosures. Research support from Juno Therapeutics. Consultant for . Sanofi. 2. 3. Lecture outline. Principles of immune regulation . Self-tolerance; mechanisms of central and peripheral . Introduction to Standard Geometrical Tolerance Datum and Tolerance Accumulation Possible Tolerance Conditions Block Example Specific Tolerances for Slip and Press Fits Machine Tolerances Tolerance Block 11455mm to 16335mm 16535mm to 22885mm 22885mm to 31140mm FIXED LIMIT GAGE FACT SHEETFixed limit gages are primarily used to check dimensions and geometries Plug gages check internal dimensions and Anna Postolova, MD MPH. Allergy/Immunology/Rheumatology. Menlo Medical Clinic. Stanford Health Care . Disclosures . Nothing to disclose. Objectives. Recognize aspects of history and presentation that are suggestive of a primary immunodeficiency or immune dysregulatory syndrome in rheumatology patients. Assistant Professor. Department of Microbiology. AIIMS, Rishikesh. Learning objectives. By the end of this session student should be able to understand:. Central and peripheral tolerance. Theories of autoimmunity. By: . Dr Puneet Kumar Gupta . Assistant Professor, Microbiology. 1. 2. 3. 4. 5. 6. 7. 8. Tolerance and Autoimmunity. 9. What is tolerance?. Mechanisms to protect from potentially self reacting lymphocytes. . immunopathology. concerns disorders caused by alterations of the immune response. 3 main categories of alterations:. . excessive response hypersensitivity reactions. inappropriate . . response . . immunological tolerance. Immunological . tolerance is a state of unresponsiveness to a particular antigen to which a person has been exposed earlier. .. . . The important aspect of tolerance is the self-tolerance, which prevents the body to mount immune response against self-antigens. LECTURE : 07 LEARNING OBJECTIVES : The student should be able to: Describe the term "autoimmune", indicate if it is either Define the term "autoantibodies". Determine if the autoantibodies eit Autoimmunity. is the system of immune responses of an organism against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease.. These . Marian . Rewers, MD, PhD. Sponsors:. Patten-Davis Foundation. Autoimmunity Screening for Kids (ASK), 2017-2022 . Screened >30,000 Colorado general population children 1-17 y old. Prevalence of pre-symptomatic T1D - 1.0% (95%CI –0.9- 1.1%).