PPT-Cholesterol Treatment Trialists’ (CTT) Collaboration

Slide deck CTT Collaboration Background History Founded in 1993 prior to publication of 4S trial in 1994 Original protocol published in 1995 Trial eligibility for inclusion in CTT Randomized. High blood cholesterol is one of the major risk factors for heart disease A risk factor is a condition that increases your chance of getting a disease In fact the higher your blood cholesterol level the greater your risk for developing heart disease AANUIIOU WELL ALANEIELOWINAUAE fats trans fats and cholesterol that includes a VAIEYOUI VEGEALEANA EEANLOW A dairy products AOILYWIEPEWEE OOELEANUOMEA IMALLVIILEAANOW AWAYEAAOOOUOEMEAEMOVEE skin from poultry 3UIUEMEALEOLOW MEAMAINIEO regular entrees But when you have too much in your blood it can build up on the walls of your arteries This can lead to heart disease and strokeleading causes of death in the United States Are you at risk About one in every six adult Americans has high cholesterol In fact the higher your blood cholesterol the greater your risk of developing heart disease or having a heart attack Heart disease is the 1 killer of men and women in the United States Each year more than a million Americans have a heart attack and It is made in the liver and released into the bloodstream You can also get cholesterol from the food you eat It is important to get your cholesterol checked and learn how to manage your cholesterol The different types of cholesterol HDL Highdensity Dr. Nikhat Siddiqi. 1. Overview. Cholesterol, the characteristic steroid alcohol of animal tissues, performs a number of essential functions in the body. . C. holesterol is a structural component of all cell membranes, modulating their fluidity, and, in specialized tissues, cholesterol is a precursor of bile acids, steroid hormones, and vitamin D. . Cholesterol is an essential lipid constituent of cell membranes. Cholesterol is a precursor of steroid hormones and of bile acids. Intermediates of cholesterol biosynthesis are required to make vitamin D and for posttranslational modification of membrane proteins. . 4. th. Stage . Dr. Dalia . Abd. Al- Kader. PhD Pharmacology. Coronary heart disease . (CHD) . is correlated with elevated levels of low-density lipoprotein cholesterol (LDL-C; “bad” cholesterol) and triglycerides and low levels of high-density lipoprotein cholesterol (HDL-C; “good cholesterol”). . Lina . Rajwani. Dinipre. . Youdubagha. .. Lipid Metabolism Disorders. Definition of Lipid metabolism. Its simply the breakdown or synthesis of lipids in a cell. Lipids are broken down for energy and can be gotten from the diet, stored and synthesized in the liver.. What are the current perspectives?. Prof. . Erik . Stroes. Academic Medical Centre. Amsterdam, The Netherlands. Is There a Therapeutic Need. . Beyond LDL Lowering ?. 1. Heart Protection Study Collaborative Group.. Chapter ABSTPurpose of review: Bile acid sequestrants (BAS) have been used for more than 50 years in the treatment of hypercholesterolemia. The last decade, bile acids are emerging as integrated regul How is it treated? Lowering high cholesterol levels is important for people at all ages, with and without heart disease. If you have high cholesterol, you will need to eat a healthy diet, exercise re ????????????????? ? Cholesterol is a fatty substance, vital for good health. It helps form cell membranes, various hormones, bile and vitamin D. We get some cholesterol from our diet but most is made Dr. Carolyn K. Suzuki. 1. To compare and contrast the properties of apolipoprotein particles (e.g. chylomicrons, LDL, HDL), with respect to their composition, metabolism and transport. . To distinguish the different biochemical pathways that can be potentially targeted pharmacologically to control plasma apolipoprotein levels and manage cardiovascular disease..