PPT-An audit of non-HDL cholesterol reporting

Rachel Randle Clinical Scientist inservice HSST Viapath Bedford Hospital Dr W Wassif Consultant Chemical Pathologist Bedford Hospital On behalf of National Clinical Biochemistry Audit Group. Learning outcome. Most cholesterol is synthesised by the liver from saturated fats in the diet. Cholesterol is a component of cell membranes and a precursor for steroid synthesis. High-density lipoprotein (HDL) transports excess cholesterol from the body cells to the liver for elimination. This prevents accumulation of cholesterol in the blood. Low-density lipoprotein (LDL) transports cholesterol to body cells. Most cells have LDL receptors that take LDL into the cell where it releases cholesterol. Once a cell has sufficient cholesterol a negative feedback system inhibits the synthesis of new LDL receptors and LDL circulates in the blood where it may deposit cholesterol in the arteries forming atheromas. A higher ratio of HDL to LDL will result in lower blood cholesterol and a reduced chance of atherosclerosis. . : Learning Outcomes. State where cholesterol is synthesised. State the type . of . diet that can increase cholesterol levels in the blood. Give 2 reasons why cholesterol is important for cellular functions. Beth Kalicki. Heli. J. Roy, PhD, RD. Pennington Biomedical Research Center. Cholesterol Trends. Blood cholesterol levels correlate with weight. However, lean individuals can have high cholesterol levels.. Cholesterol is an essential lipid constituent of cell membranes. Cholesterol is a precursor of steroid hormones and of bile acids. Intermediates of cholesterol biosynthesis are required to make vitamin D and for posttranslational modification of membrane proteins. Arterio. sclerosis. Thickening/Hardening of Arteries. Predominantly . Athero. sclerosis. Normal vessel structure. Pathophysiology of Brain & Body . USSJJQ-20-3. Normal Structure. Normal Structure. Plasma lipids . 200 . Lipoproteins . 201 . Fatty acids . 200 . Disorders of lipid metabolism . 207 . Cholesterol . 201 . Investigation of hyperlipidaemias . 214 . FATTY ACIDS . Lipids play a critical role in almost all aspects of . What are the current perspectives?. Prof. . Erik . Stroes. Academic Medical Centre. Amsterdam, The Netherlands. Is There a Therapeutic Need. . Beyond LDL Lowering ?. 1. Heart Protection Study Collaborative Group.. ????????????????? ? Cholesterol is a fatty substance, vital for good health. It helps form cell membranes, various hormones, bile and vitamin D. We get some cholesterol from our diet but most is made Chole lipoproteins, which got their name because they’re made of fat (lipid) and proteins. The two types of lipoproteins that carry cholesterol to and from c ells are low - density lipoprotein, or holesterol. When you have your blood it can build up the inner walls of your heart arteries. Over time this forms plaque. Plaque narrows your arteries and puts you at an increased risk for having a into cardiovascular protection []. Furthermore, as some glucose-lowering medications have shown to increase the risk for major adverse cardiovascular events (MACE), regulatory agencies require that al Toll Free: 800-445-9853 Fax: 734-483-1592 www.pointescientific.com For the quantitative determination of High Density Lipoprotein (HDL) in Cholesterol in serum. Early methods of H , MD, FRCPC, FACP, CCD, ECNU.. Asst. Professor and Consultant . Medicine, Endocrinology. Department of Medicine, King Saud University. Lipid Transport. LPL/Apo C2. Rader DJ, Daugherty, A Nature 2008; 451:904-913 . Prof. Ulf . Landmesser. University Hospital Zürich. Zürich, . Switzerland. Acute coronary syndromes result most frequently from coronary plaques without significant stenosis. Plaque in mid RCA. Occluded RCA.