PPT-Drugs Employed in the Treatment of Gout

Hayder B Sahib M Sc D Sc B Sc Pharm Gout is a metabolic disorder characterized by high levels of uric acid in the blood Hyperuricemia can lead to deposition of sodium . Gout. and Hyperuricemia. By:. RS. Objectives. Definition. Epidemiology. Etiology. Pathophysiology:. overproduction of uric acid. Pathophysiology:. underexcretion . of uric acid. majority of patients (80% to 90%) with gout have a. Prevalence is greater in men (5.9%; 6.1 million) than women (2.0%; 2.2 million). Prevalence has increased by 1.2% points over the past 2 decades. Incidence of gout 2x greater among black men than white men. Prevalence is greater in men (5.9%; 6.1 million) than women (2.0%; 2.2 million). Prevalence has increased by 1.2% points over the past 2 decades. Incidence of gout 2x greater among black men than white men. Gout. The most common cause of inflammatory arthritis in US adults (3.9% of Americans; approx. 8.3 million people; 2007-2008). Prevalence is greater in men (5.9%; 6.1 million) than women (2.0%; 2.2 million). GOUT. GOUT. 2. Gout results from the precipitation of . urate. crystals in the tissues and the subsequent inflammatory response.. Acute gout usually causes an painful distal arthritis, but it also can cause joint destruction, subcutaneous deposits (tophi), and renal calculi and damage.. Drugs Used in Gout. The selective COX-2 inhibitors are a new group of drugs that provide potent . antiinflammatory. activity without causing significant . GI toxicity. . Celecoxib , . the first selective . calcitonin. BONE REMODELING. Throughout life, bone is continuously remodeled, with about 10% of the adult skeleton replaced each year. . The purpose of bone remodeling is to remove and replace damaged bone and to maintain calcium homeostasis.. Heart of England NHS Foundation Trust. Overview. Background. Diagnosis. Risk factors. Acute treatment. Long-term treatment. Pseudogout. Gout. Inflammatory arthritis due to monosodium urate crystal deposition. purine. bodies in blood pre gout.. Whereas, the kidney is unable to separate this combination of uric acid and . purine. bodies.. Then the uric acid salts accumulate in the blood.. PTO... Dr. . Sura. Al . Zoubi. MMS . Pharmacology. . Lecture 3. Revision. Gout. The term . gout . describes a disease spectrum including hyperuricemia, . recurrent attacks . of acute arthritis associated with monosodium urate crystals .       3 to gout are. Gout are was specied as the only critical outcome for management of lifestyle factors. All other outcomes were specied as important. Without standa Define gout . Describe outlines of treatment. Describe treatment of acute gouty arthritis . Describe the mechanism of action , clinical uses & side effects of drugs used in acute attacks. OBJECTIVES ( continue). Mohammed. M.B.Ch.B. / MSc. Clinical pharmacology. Gout. is a . metabolic. disorder characterized by . high levels of uric acid. in the blood (hyperuricemia) due to an imbalance between overproduction of uric acid and/or the inability to excrete uric acid . Al . A. sadi. M.B.Ch.B. , MSc pharmacology. December 2022. Learning Objectives:. 1. . Definition and Pathophysiology . of gout. 2. C. auses . that precipitate . gout. 3. Drugs used for acute gout. 4. Colchicine in acute attack of gout.