PPT-PURINE METABOLISM AND GOUT

One of the important specialized pathways of a number of amino acids is the synthesis of purine and pyrimidine nucleotides These nucleotides are important for a number of reasons Most of them not just ATP are the sources of energy that drive most of our reactions. C483 Spring 2013. 1. A . ribose sugar is added to ________ rings after their synthesis and to ________ rings during their synthesis.. A) purine; pyrimidine. B) pyrimidine; purine. C) purine; purine. D) pyrimidine; pyrimidine. P. 1 DIET (For Patients With Gout) 1. Reduce intake of high fat foods such as oil, butter, margarine, lard, chicken fat, mayonnaise, salad dressing, cheese, whole milk, cream, coconut milk, pastries Purine catabolism. Purine degradation. Purine Salvage Pathway. From normal turnover of cellular nucleic acids. Obtained from the diet. Reutilization of adenine, hypoxanthine, and guanine. Two enzymes:. De Novo. Synthesis of . Purine. Nucleotides. We use for . purine. nucleotides the entire . glycine. molecule (atoms 4, 5,7), the amino nitrogen of . aspartate. (atom 1), amide nitrogen of glutamine (atoms 3, 9), components of the . Metabolism. Dr. Anissa Atif Mirza. Synopsis. Fates of dietary Nucleoproteins/Nucleic Acids.. De novo Biosynthesis of Purines and Pyrimidines.. Salvage of Purines and Pyrimidines. Catabolism of Purines and Pyrimidines. Dr. Anissa Atif Mirza. Synopsis. Fates of dietary Nucleoproteins/Nucleic Acids.. De novo Biosynthesis of Purines and Pyrimidines.. Salvage of Purines and Pyrimidines. Catabolism of Purines and Pyrimidines. Heart of England NHS Foundation Trust. Overview. Background. Diagnosis. Risk factors. Acute treatment. Long-term treatment. Pseudogout. Gout. Inflammatory arthritis due to monosodium urate crystal deposition. Kumar. Nucleotide Metabolism. PURINE RIBONUCLEOTIDES: formed . de novo. i.e., purines are . not. initially synthesized as free bases. First purine derivative formed is Inosine Mono-phosphate (IMP). purine. bodies in blood pre gout.. Whereas, the kidney is unable to separate this combination of uric acid and . purine. bodies.. Then the uric acid salts accumulate in the blood.. PTO... Acid. M.sc.. . Duaa. . falah. pharmacology and toxicology. Uric acid. It is . the final breakdown product of purine metabolism. it circulates in the plasma as sodium urate and is excreted by the kidney. It is derived from nucleic acid that are ingested or come from destruction of tissue cell .. Met.. Purine. Met.. Learning Objectives. 1. How . Are Purines Synthesized? . 2. . How Are Purines Catabolized?. 3. . How Are . Pyrimidines. Synthesized and . . . Catabolized. ?.  . 4. . How Are . Gout is a systemic disease caused by excess uric acid as the result of deficient purine metabolism. Clinically, gout is marked by peripheral arthritis and painful inflammation in joints resulting fro Sweetbreads sardines, fish eggs, shrimp Spinach Whole grains Processed baked goods Gout is painful arthritis common in people with kidney disease. Since purine or uric acid is usually excreted in uri Most cells actively turnover their. N.A.’s. especial RNA’s. This results in . the release . of adenosine, adenine, guanine. and . hypoxanthine. These are recovered. thru . salvage pathways. .