PPT-PURINE METABOLISM AND GOUT

One of the important specialized pathways of a number of amino acids is the synthesis of purine and pyrimidine nucleotides These nucleotides are important for a number of reasons Most of them not just ATP are the sources of energy that drive most of our reactions. C483 Spring 2013. 1. A . ribose sugar is added to ________ rings after their synthesis and to ________ rings during their synthesis.. A) purine; pyrimidine. B) pyrimidine; purine. C) purine; purine. D) pyrimidine; pyrimidine. Metabolism. Dr. Anissa Atif Mirza. Synopsis. Fates of dietary Nucleoproteins/Nucleic Acids.. De novo Biosynthesis of Purines and Pyrimidines.. Salvage of Purines and Pyrimidines. Catabolism of Purines and Pyrimidines. Prevalence is greater in men (5.9%; 6.1 million) than women (2.0%; 2.2 million). Prevalence has increased by 1.2% points over the past 2 decades. Incidence of gout 2x greater among black men than white men. hyperuricemia. , . recurrent attacks of acute arthritis associated with . monosodium . urate. . crystals in . leukocytes. . found in synovial fluid, . deposits of monosodium . urate. crystals in tissues,. Prevalence is greater in men (5.9%; 6.1 million) than women (2.0%; 2.2 million). Prevalence has increased by 1.2% points over the past 2 decades. Incidence of gout 2x greater among black men than white men. Dr.. Anil Kumar. (Medicine) Asst. Professor. . Dept. of VCC. GOUT. Introduction:. The term . “gout” . in general term refers to a form of inflammatory arthritis.. Kumar. Nucleotide Metabolism. PURINE RIBONUCLEOTIDES: formed . de novo. i.e., purines are . not. initially synthesized as free bases. First purine derivative formed is Inosine Mono-phosphate (IMP). purine. bodies in blood pre gout.. Whereas, the kidney is unable to separate this combination of uric acid and . purine. bodies.. Then the uric acid salts accumulate in the blood.. PTO... Dr. . Sura. Al . Zoubi. MMS . Pharmacology. . Lecture 3. Revision. Gout. The term . gout . describes a disease spectrum including hyperuricemia, . recurrent attacks . of acute arthritis associated with monosodium urate crystals . Acid. M.sc.. . Duaa. . falah. pharmacology and toxicology. Uric acid. It is . the final breakdown product of purine metabolism. it circulates in the plasma as sodium urate and is excreted by the kidney. It is derived from nucleic acid that are ingested or come from destruction of tissue cell .. Met.. Purine. Met.. Learning Objectives. 1. How . Are Purines Synthesized? . 2. . How Are Purines Catabolized?. 3. . How Are . Pyrimidines. Synthesized and . . . Catabolized. ?.  . 4. . How Are . Most cells actively turnover their. N.A.’s. especial RNA’s. This results in . the release . of adenosine, adenine, guanine. and . hypoxanthine. These are recovered. thru . salvage pathways. . Bryant England, MD, PhD. University of Nebraska Medical . Center. Omaha, NE, USA. Key message. Multimorbidity is growing problem that is associated with poor long-term health outcomes.. Of the four rheumatic and musculoskeletal diseases (RMDs) examined in RISE, the prevalence of multimorbidity was highest in gout, similar in RA and . MacDonald T, et al. . Long Term Cardiovascular Safety of Febuxostat and Allopurinol in Patients with Chronic Gout: The Febuxostat versus Allopurinol Streamlined Trial (on Behalf of the FAST Investigators) - ACR Meeting Abstracts (acrabstracts.org).