and strains U l102 and Z29 Z29 Subsequent work has shown that isolates can be discriminated into into 11 14 which extend across the the iv Nucleotide sequence analysis also supports the existence ID: 960313
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X TT I T Virology Division herpesvirus-6 strain strain Subsequent isolations U 1102) and strains U l102 and Z29 Z29 Subsequent work has shown that isolates can be discriminated into into 11, 14], which extend across the the (iv) Nucleotide sequence analysis also supports the existence of two groups of HHV-6 isolates, but shows that these groups are very closely related to each other and that each contains a degree of heterogeneity, with some regions more variable than oth
ers. Sequences (0.2kb to 2.5 kb) from plasmid clones or polymerase chain reaction amplification products from eight different regions of the genome of laboratory reference strains [-15, 16], recent clinical isolates and strains from tissue samples [5, 11, 14] showed that nucleotide sequence identity ranged from 97 to 100% within groups and from 94% to 96% between groups and predicted amino acid sequences between groups. 95 % [ t t 10, 11], with the exception of two patient
s from whom both both HHV-6 isolated from immu- nocompromised adults may belong to either group [1-6, 11, 14], and in one have been isolated isolated The prevalence of each group in the population and group can the differential unknown, and of HHV-6 U 1102-tike 1102-tike for naming the two closely related groups of HHV-4 HHV-4 It was further agreed that these issues would be discussed at the 18th International Herpesvirus Workshop, to be held in in the Virology Division N
ews in patients 234: 596- N, Serwadda of human Proc Natl H (1991) Several herpesvirus-6 strains N (1990) S, Pfeiffer isolates. J P, Buch- Methods 21:179-190 4 + T cells. Gompels UA, Carrigan D, J (1993) Virology 191:523-528 AL, Sun determinants encoded E (1990) virus types genes. J 4, L° M. Jones de la Pitie-Salpetriere, Bologna, Bologna, PA, U.S.A., Herpesvirus Branch, Control, Atlanta, CA, U.S.A., University, Osaka, 4-6, A-1201 California Davis, Davis, Verlagsort: Wien