PDF-The Molecular Basis of Blood Coagulation Review

Bruce Furie and Barbara C Furie Center for Hemostasis and Thrombosis Research Division of HematologyOncology Departments of Medicine and Biochemistry New England Medical Center and Tufts University. Abnormalities of Blood Coagulation. Learning Objectives. Describe functions of blood vessels and platelets in controlling bleeding. Explain three phases of coagulation and the respective factors involved. Prof . Khaled. . Yassen. MD FFARCSI. Department of . Anaesthesia. Liver Institute, . Menoufiya. University, Egypt.. kyassen61@hotmail.com. Old and New Liver Institute, . Menoufiya. University, Egypt. Thrombocytes. Platelets (Thrombocytes). 2- 4 micromillimeters in diameter. 250,000 – 400,000 per microliter . (too few thrombocytopenia – too many thrombocytosis). Lifespan on average 6 – 10 days. Thrombocytes. Platelets (Thrombocytes). 2- 4 micromillimeters in diameter. 250,000 – 400,000 per microliter . (too few thrombocytopenia – too many thrombocytosis). Lifespan on average 6 – 10 days. I-. Deficiency of Coagulation Factors. II-. HYPERCOAGULABLE STATES . I-. Deficiency of Coagulation Factors. Treatment. AQUIRED DISORDERS. OF. BLOOD COAGULATION. ACQUIRED DISORDERS. OF. BLOOD COAGULATION. Acquired coagulation disorders:. They are . more common. than the inherited disorders. Unlike the inherited disorders, . multiple clotting. factor deficiencies are usual.. The acquired coagulation disorders.. Acquired coagulation disorders:. They are . more common. than the inherited disorders. Unlike the inherited disorders, . multiple clotting. factor deficiencies are usual.. The acquired coagulation disorders.. Guy Young, MD. Children’s Hospital Los Angeles. University of Southern California Keck School of Medicine. Abbreviations. Abbreviations will be explained the first time the term appears on a slide. haemostasis. Vascular bleeding disorders:. .The underlying . abnormalities are. either in the . vessels themselves. . perivascular. connective tissue. .. Each could be. Inherited. Acquired. . autosomal. Maclennan D, Bartlett S, Cassels A, McBain I, Tompkins K, . Mcauley. S, . Cvoro. V; Ward 42, Victoria Hospital, Hayfield road, Kirkcaldy, KY2 5AH e-mail: david.maclennan@nhslothian.scot.nhs.uk. abstract. According to Howell Theory of blood coagulation , the change of fibrinogen into fibrin is caused by thrombin which in fluid exists as prothrombin. The conversion of prothrombin to thrombin depends on the action of thromboplasin and calcium. . Professor . Dr.Noori. Mohammed . Luaibi. HEMOSTASIS EVENTS . The . term hemostasis means prevention of blood loss. Whenever a vessel is severed or ruptured, hemostasis is achieved by several mechanisms: (. Nervana. . Bayoumy. . Associate . Professor. Department of Physiology. . Objectives. At the end of this lecture . you . should be able to:. Recognize the different clotting factors. U. nderstand the role of calcium ions during clotting cascades.. Platelets. (Thrombocytes) …. Are small, irregularly-. shaped,oval. non-. neocleated. cells, 2-3 µm in diameter, . derived from fragmentation of precursor megakaryocytes (bone marrow). The average lifespan of a platelet is between 8 and 12 days. .