PDF-The Molecular Basis of Blood Coagulation Review

Bruce Furie and Barbara C Furie Center for Hemostasis and Thrombosis Research Division of HematologyOncology Departments of Medicine and Biochemistry New England Medical Center and Tufts University. Abnormalities of Blood Coagulation. Learning Objectives. Describe functions of blood vessels and platelets in controlling bleeding. Explain three phases of coagulation and the respective factors involved. Tube Method . Mr. Mohammed A. Jaber. Coagulation Time ( Clotting Time) CT.. Clotting time was used as a screening test to measure all stages in the intrinsic coagulation system and to monitor heparin therapy .. By: . Jingtian. . Weng. , Cindy Nguyen, Cassandra Lee, Sarah Bento-De Sousa. Presentation Date: Sept. 13, 2016. PHM142 Fall . 2016. Instructor: Dr. Jeffrey Henderson. What is COX?. Two homodimer enzymes COX-1 and COX-2. ARP-01M. «. Mednord. ». Russia. , . 634029 . . . Tel/fax. : (3822) 52-75-22 . Tomsk. . . . www. .. mednord. -. t. .. ru. Sulistyo. . Rini. , . MSc. Five Stages of . Hemostasis. Vessel spasm. Formation of the platelet plug. Blood coagulation or development of an insoluble fibrin . clot. Clot retraction . Clot dissolution . haemostasis. Vascular bleeding disorders:. .The underlying . abnormalities are. either in the . vessels themselves. . perivascular. connective tissue. .. Each could be. Inherited. Acquired. . autosomal. :. are additives that inhibit clotting of blood and/or plasma. They act either by binding calcium ions or by inhibiting thrombin activity. . Platelets and coagulation factors are activated when blood vessels are punctured, and their activation continues in sample containers that do not contain anticoagulant, leads to clot formation which interfere with many analytical tests.. M. AND J. E. WYNANDS, M.D., C.IVI.~ THE V~Y F_~aLY STUVmS of this subject, many controversies existed regard- ing the various factors and mechanisms involved in the dotting process. One simply has to Dr. shatha Sami alyasrri. Assistant professor . Bleeding disorders during pregnancy and . delivery. . A. Inherited . Vascular abnormalities. Platelet disorders. Coagulation disorders. B.Acquired. Thrombocytopenia. According to Howell Theory of blood coagulation , the change of fibrinogen into fibrin is caused by thrombin which in fluid exists as prothrombin. The conversion of prothrombin to thrombin depends on the action of thromboplasin and calcium. . Professor . Dr.Noori. Mohammed . Luaibi. HEMOSTASIS EVENTS . The . term hemostasis means prevention of blood loss. Whenever a vessel is severed or ruptured, hemostasis is achieved by several mechanisms: (. The stoppage of . bleeding. or . hemorrhage. The normal . haemostatic. response; . to vascular damage depends on a closely linked interaction between the . blood vessel wall. , . circulating platelets. Nervana. . Bayoumy. . Associate . Professor. Department of Physiology. . Objectives. At the end of this lecture . you . should be able to:. Recognize the different clotting factors. U. nderstand the role of calcium ions during clotting cascades.. Platelets. (Thrombocytes) …. Are small, irregularly-. shaped,oval. non-. neocleated. cells, 2-3 µm in diameter, . derived from fragmentation of precursor megakaryocytes (bone marrow). The average lifespan of a platelet is between 8 and 12 days. .