PPT-Characterizing the Skeletal Phenotype of

dbdb Mice Student Bailey Lindenmaier Mentors Dr Russell Turner amp Dr Urszula Iwaniec Skeletal Biology Lab Introduction Age related Osteoporosis Porous bone 1 in 3 women and 1 in 5 men over the age of 50 worldwide are estimated to have osteoporosis. Yu Chen. 1 . Tae-. Kyun. Kim. 2. Roberto Cipolla. 1.  . University of Cambridge, Cambridge, UK. 1. Imperial College, London, UK. 2.  . Problem Description. Task: To identify the phenotype class of deformable objects.. Support: bones help support and provide shape to the body. Protection: provides protection to internal organs. Mineral storage: calcium and phosphorus make bones strong and help with oxygen. Hemopoiesis. System. No . bones about it!. 5 . Functions of the Skeletal System…. Provides shape . and supports . for . body. Allows for movement. Protects internal organs. Stores materials (calcium and lipids). and plant phenotypes. George . Gkoutos. Phenotype And Trait Ontology (PATO). The meaningful cross . species and across domain . translation of phenotype is essential .  . phenotype-driven gene function discovery and comparative pathobiology . 1. Gives shape and support. 2. Protects internal organs. (Skull, Rib-cage). 3. Muscles attach to bones.. 4. Blood cells are formed in bone marrow. . 5. Calcium and Phosphorous storage. . http://kidshealth.org/kid/htbw/SSmovie.html. Take out your HW (. annotated. “Lamb to the Slaughter” and written analysis). . Pick any part of the story (a paragraph, a few paragraphs, one sentence, etc.) and draw a big box around it. . Then, on the back of your copy of the story, . Quietly find your seat and get ready for class. Hand in skeleton projects below on chair. Fun Questions. How many bones are in the human body?. Have you ever broken a bone?. What is the largest bone in your body?. Learning Objectives. Describe the . anatomy . and . physiology . of skeletal muscle. Role of muscle fiber types as it relates to different types of athletic performances. Histochemical . techniques for identification of muscle fiber types. Changes in genotype can result in changes in phenotype.. Watch the following videos . http://www.bozemanscience.com/mutations. http://www.bozemanscience.com/001-natural-selection. http://www.bozemanscience.com/034-mechanisms-that-increase-genetic-variation. Warm up. What is the purpose of the skeletal system?. Week 4, Day Four. Warm up Response . Purpose:. to provide structure and support to the human body. Bones are where new blood cells are generated (in the marrow), and require the mineral . Sample & Methods. . 100 index cases (IC): 87 adults and 13 children; 8 were severe forms. . Identifies variants were traced in 36 relatives. NGS panel: LDLR, APOB, PCSK9, LDLRAP1 and APOE . (. It’s best to view this in . Slide Show . mode, especially for the quizzes.. This module will take approximately 75 minutes to complete.. The quiz for this module is long, and includes significant previous material from this and other blocks.. 559V Cartilage-hair hypoplasia is a rare, autosomal recessive skeletal dysplasia,caused by mutations in the gene. The skeletal abnormalities include CCCCCAAAAASSSSSEEEEE R R R REEEEPPPPPOOOOORRRRRTTT Degeneration Figure Legend:Figure 1Skeletal muscleDegeneration in a male Harlan SpragueDawley rat from a subchronic study. A central myofiber is swollen and hypereosinophilic(arrows), and a fragmented