PPT-Characterizing the Skeletal Phenotype of

dbdb Mice Student Bailey Lindenmaier Mentors Dr Russell Turner amp Dr Urszula Iwaniec Skeletal Biology Lab Introduction Age related Osteoporosis Porous bone 1 in 3 women and 1 in 5 men over the age of 50 worldwide are estimated to have osteoporosis. and plant phenotypes. George . Gkoutos. Phenotype And Trait Ontology (PATO). The meaningful cross . species and across domain . translation of phenotype is essential .  . phenotype-driven gene function discovery and comparative pathobiology . Know the structure and functions of the skeletal system. Know the roles that the skeletal system performs. Functions of the skeletal system. With a partner discuss the functions of your skeleton. How many of the 5 functions can you identify?. 1. Gives shape and support. 2. Protects internal organs. (Skull, Rib-cage). 3. Muscles attach to bones.. 4. Blood cells are formed in bone marrow. . 5. Calcium and Phosphorous storage. . http://kidshealth.org/kid/htbw/SSmovie.html. Quietly find your seat and get ready for class. Hand in skeleton projects below on chair. Fun Questions. How many bones are in the human body?. Have you ever broken a bone?. What is the largest bone in your body?. Sabrina Barner, Abbe Carlin, Amber Weigle. Neuromuscular Junctions. Communication link between nervous system and skeletal muscle fiber. Specialized intercellular connection. Each skeletal muscle fiber is controlled by a nerve cell. Quietly find your seat and get ready for class. Hand in skeleton projects below on chair. Fun Questions. How many bones are in the human body?. Have you ever broken a bone?. What is the largest bone in your body?. Changes in genotype can result in changes in phenotype.. Watch the following videos . http://www.bozemanscience.com/mutations. http://www.bozemanscience.com/001-natural-selection. http://www.bozemanscience.com/034-mechanisms-that-increase-genetic-variation. Michael Johnson. 1. , Thomas Villani. 1, . Nick Crider. 1. ,Colleen Wojenski. 2 . 1. Visikol Inc., North Brunswick, NJ, 08902, 2. Product Safety Labs, Dayton, NJ, 08810. Abstract. Developmental and reproductive toxicology (DART) studies are required for new chemical entities going to market to ensure that there are not adverse developmental consequences associated with the chemical. These studies involve dosing a pregnant female animal (e.g. mouse, rat, rabbit) with the compound and evaluating the effect of the chemical on the offspring. This evaluation involves the parallel processes of histopathology and gross morphological evaluation wherein the most time-consuming component of DART studies is the performance of gross skeletal evaluation. Since the introduction of Thalidomide into the marketplace, close attention has been paid to the impact of chemicals on skeletal development and DART studies require the visualization of gross skeletal morphology for abnormalities. The current methodology for conducting skeletal evaluation involves digesting soft tissue using a strong base (potassium hydroxide) and staining the bone with alizarin and cartilage in some cases with . Warm up. What is the purpose of the skeletal system?. Week 4, Day Four. Warm up Response . Purpose:. to provide structure and support to the human body. Bones are where new blood cells are generated (in the marrow), and require the mineral . What is the process of bone formation?. What are the structures of the long bones?. What are the structures of the skeletal system? . The skeletal system. Compromises the bony framework of the body.. http://. www.abcya.com/skeletal_system.htm. S. k. e. l. e. t. a. l. System. Objective. : By the end of the lesson students will be able to list (3) bones in the body, as well as explain (2) functions of the skeletal system.. 559V Cartilage-hair hypoplasia is a rare, autosomal recessive skeletal dysplasia,caused by mutations in the gene. The skeletal abnormalities include CCCCCAAAAASSSSSEEEEE R R R REEEEPPPPPOOOOORRRRRTTT Degeneration Figure Legend:Figure 1Skeletal muscleDegeneration in a male Harlan SpragueDawley rat from a subchronic study. A central myofiber is swollen and hypereosinophilic(arrows), and a fragmented Functions of the Skeletal System. Form. Protection. Support. Strength. How does it work?. Bone. - Hard tissue that supports and protects other organs. Cartilage. - . Firm, flexible tissues that .