PPT-AKI & CKD

Josh Exley Learning Objectives Acute Kidney Injury Drugs and the Kidney Chronic Kidney Disease Normal Kidney function Kidney Functions Excretory function Filter metabolites toxins drugs Homeostatic function. Pro: Andy Stein. Con: Dan Ford. Chair: Prof. Higgins. Tuesday, 5. th. November 2013, 1-2pm. CSB Room 00067. The expanding definition of CKD is unnecessarily labelling many people as diseased: Summary. What is acute kidney injury (AKI). Hyperkalaemia. What is chronic kidney disease (CKD). Case/off. So what is an AKI?. Significant deterioration in renal function over hours/days. How would you define that clinically?. Metformin must be considered the cornerstone of treatment when not contraindicated (eGFR <30). In patients not at goal on metformin monotherapy, adding an SGLT. 2. inhibitor like empagliflozin is warranted when not contraindicated (eGFR <45). ( ) CVD benefit ?Class effect?. in Neonates. Jordan M. Symons, MD. University of Washington School of Medicine. Seattle Children’s Hospital. Seattle, WA. 9. th. International . pCRRT. Conference on . Pediatric Continuous Renal Replacement Therapy. Professor of Pediatrics. University of Cincinnati College of Medicine. Director, Center for Acute Care Nephrology. Nephrology and Hypertension. The Heart Institute. Cincinnati Children’s Hospital Medical Center. Figure i.1 Prevalence of CKD by stage among NHANES participants, 1988-2012. Vol . 1, CKD, . Ch. . i. 2. Stages of CKD – KDOQI 2002 Definitions. Stage 1: eGFR ≥ 90 ml/min/1.73m. 2. and ACR ≥ 30 mg/g. 1 Table 1.1 Distribution of NHANES participants with diabetes, self-reported cardiovascular disease, & single sample markers of CKD, 2007-2012. Data Source: National Health and Nutrition Examination Survey (NHANES), 1988–1994, 1999-2004 & 2005–2012 participants age 20 & older. Note: Cardiovascular disease designation is based on self-report of any CVD condition (see CKD Analytical Methods chapter for detail); CKD is defined as eGFR <60 or ACR ≥30. Abbreviations: ACR, urine albumin/creatinine ratio; CKD, chronic kidney disease; SR CVD, self-reported cardiovascular disease; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; . not applicable.. A - versible increase in the blood concentra�on of crea�nine and nitrogenous waste products and by the inability of the kidney to regulate �uid and elec - trolyte ho CONTENTS. Introduction. Pathophysiology. Clinical and laboratory features. Prophylaxis and treatment. . . KDIGO Guideline Co-Chairs:. Alfred K. Cheung, MD. Johannes F.E. Mann, MD. Guideline: . Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney Int. 2021;99(3S):S1–S87. Martha Cannon . BA VetMB DSAM(Fel) RCVS Specialist in Feline Medicine. Oxford Cat Clinic. Definitions. Acute kidney injury (AKI): . sudden damage to an otherwise healthy kidney. +/- loss of function, spectrum from mild to severe. . 20% - 50%. What you should know…. Acute renal failure or Acute kidney injury?. What means AKI?. Most frequent causes involved?. How to identify an AKI?. Where from should start our therapy? . Renal replacement therapy – when to start?. Dr Jon Murray. Consultant . Nephrologist. James Cook University Hospital. Acute Kidney Injury v Chronic Kidney Disease. Creatinine 1250 . . mol. /l. What are the priorities?. How is the patient? Is this single or multi-organ failure?. (FENOLDOPAM, EARLY PD) . STEFANO PICCA and ZACCARIA RICCI. Dialysis . Unit- . Dept. . of Nephrology . and Urology. CICU- . Dept. of Cardiology, . “. Bambino . Gesù. ” Pediatric Research Hospital.