PPT-Hemoglobin Variation Dr Sunita Mittal

Learning Objectives Different Hemoglobin variants Characteristics of Hemoglobin variants and Hb Different Hemoglobin combinations Hemoglobin V ariants There must be . b. d. g. a. a. Chromosome 16. Chromosome 11. 25%. 25%. a. a. b. d. g. 25%. 25%. 48%. 48%. 1.5%. 0.5%. 1.5%. 0.5%. Hemoglobin synthesis. a. a. a. a. a. a. b. g. d. b. d. g. HbA. HbF. HbA. 2. 98%. ~1%. Electrophoresis. Electrophoresis. Electrophoresis is a means of separating hemoglobin's. . . It depends on the migration of the hemoglobin molecules dissolved in a buffer on, or in, a supporting medium when an electric current is passed through them.. Hemoglobin variant trait is common and can occur in any race or ethnicity You may have heard of sickle cell trait before while not exactly the same sickle cell trait and hemoglobin variant trait are s Adult male: 4.6 – 6 million. Adult female: 4.2 – 5 million. Red blood cells are: . Tiny, flexible biconcave discs. Lacks a nucleus. Can bend when going through tiny capillaries. RBC’s are constantly manufactured. Learning Objectives. ▪ . Hemoglobinopathies. (Abnormal . Hb. . variants). ▪. Different . Hemoglobin . combinations-. Nr. and . Abn. •. Sickle . cell trait is the . heterozygous form . of the . globin. chains. Abnormalities in these proteins are referred to as . hemoglobinopathies. Two hemoglobin gene clusters are involved in the production of hemoglobin and are located at the end of the short arm of chromosomes 16 and 11, respectively. . . By – . Dr. Sunita Mittal. Learning Objectives. ▪. Iron metabolism . ▪. Hemoglobin catabolism (Fate of old RBCs) . ▪. Prehepatic. Jaundice. Iron . (Fe. +2. ) Metabolism. Iron is essential for . Svjetlana Kalanj Bognar (. svjetla. na.kalanj.bognar. @mef.hr. ). Myoglobin. . and. hemoglobin, . oxygen-binding. . proteins. evolutionary. . demands. . of. . multicellular. . organisms. . and. Learning Objectives. Introduction to Immunity. Innate Immunity. Lymphoid Tissue. Introduction to Immunity. Immunitas. : Freedom from. Immunity is the ability of body to destroy potentially hazardous/harmful foreign substances, if entered in body, that is it provides FREEDOM from any foreign invader.. Hemoglobin is the protein molecule in red blood cells that carries oxygen from the lungs to the body's tissues and returns carbon dioxide from the tissues back to the lungs.. Hemoglobin. Hemoglobin (. Hemoglobin E trait is common and can occur in any race or ethnicity. It is most common in individuals of Southeast Asian descent. You may have heard of sickle cell trait before, while not exactly the FAE — Provider Fact Sheet TRAIT Result: Blood Spot Screen Result Notication Next Steps Please take the following recommended ac�ons: Discuss the result with the family at the Hemoglobin. . Found in the RBC.. Responsible for carrying oxygen to all cells in the body.. Also binds to carbon dioxide and carries it to the lungs from the cells to be released.. Buffer against change in [H. Repco Home Finance (NSE – REPCOHOME) Mittal Consulting www.katalystwealth.com 20-20 Investing Accelerator Summit Date: 23rd Aug’24 1 About me Ekansh Mittal Founder, Katalyst Wealth (www.katalystwealth.com) SEBI Registered Research Analyst